4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group.
Definition
4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group. It has a role as an allergen, a plant metabolite and an Escherichia coli metabolite. It is functionally related to a benzoic acid. It is a conjugate base of a 4-carboxyanilinium. It is a conjugate acid of a 4-aminobenzoate. It is a tautomer of a 4-ammoniobenzoate.
Source: PubChem
US FDA substance register · UNII TL2TJE8QTX · registered name Aminobenzoic acid · single chemical substance
PABA is the aromatic acid that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · China · European Union · South Korea · United Kingdom
- Restricted or banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · Japan · South Korea
Source: EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
United States
- Specific Limitations and Comments : Use of the term "sunscreen" or similar sun protection wording in a product's labeling generally causes the product to be subject to regulation as a drug or a drug/cosmetic, depending on the claims. However, sunscreen ingredients may also be used in some cosmetic products to protect the products’ color. The labelling must also state why the sunscreen ingredient is used, for example, "Contains a sunscreen to protect product color." If this explanation isn’t present, the product may be subject to regulation as a drug (21 CFR 700.35). For more information on sunscreens, refer to Tanning Products
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 167
Restriction II/167 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name PABA: 本品は、次の化学式で表される芳香族化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 150-13-0
- EC No.EU chemical inventory number
- 205-753-0
- DTXSIDUS EPA chemical ID
- DTXSID6024466
- DTXCIDUS EPA compound ID
- DTXCID404466
- IUPAC
- 4-Aminobenzoic acid
- Molecular formula
- C7H7NO2
- Molecular weight
- 137.138 g/mol
Measured properties
- Appearance
- P-aminobenzoic acid appears as colorless crystals that discolor on exposure to light and air. (NTP, 1992) · Light beige, odorless solid, pure form is white, discolor on exposure to light and air, [Hawley] White crystalline solid, [MSDSonline]
- Odour
- Odorless · odourless
- Melting point
- 370 to 372 °F (NTP, 1992) · 188.5 °C
- Solubility
- 6110 mg/L (at 30 °C) · In water, 5,390 mg/L at 25 °C, 6,110 mg/L at 30 °C
- Density
- 1.37 (NTP, 1992) - Denser than water, will sink
- Stability
- Chemical stability: Stable under recommended storage conditions. · Conditions to avoid: Exposure to light. May discolor on exposure to air and light.
- pH
- pH (0.5% solution): 3.5 · 3.5 ()
- Dissociation constant
- 4.874 · 2.38 (at 25 °C)
- Melting/freezing point
- 187~189 ℃
- Flash point
- &, gt, 93.3 ℃
- Water solubility
- 6110 ㎎/ℓ (at 30C)
- Relative density
- 1.374 ()
- n-Octanol/water partition coefficient (Kow)
- 0.83
- Molecular weight
- 137.14
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- UV stabilizer6
- No specific technical function1
- Flavouring and nutrient1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) not reported according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) not reported according to
Source: US EPA CompTox dashboard
Related literature
- SODIUM PARA-AMINOBENZOATE ("PABA") IN THE TREATMENT · 2010
- Synthesis, Characterization and Sunscreen Protection Factor of Novel Synthesized Para Amino Benzoic Acid (PABA) Esters · 2019
- Risk Assessment of Ethylhexyl Dimethyl PABA in Cosmetics · 2019
- Antifungal Metabolite p-Aminobenzoic Acid (pABA): Mechanism of Action and Efficacy for the Biocontrol of Pear Bitter Rot Disease. · 2019
- Improved Ex Vivo Transcutaneous Permeation of Diclofenac from Solid Lipid Nanoparticles in the Presence of Novel Long-Chain Alkyl Esters of PABA · 2011
Linked databases 24
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- EU SCCS safety opinions
- IARC carcinogen classification
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese