Hexadecanamide is a fatty amide that is the carboxamide derived from palmitic acid.
Definition
Hexadecanamide is a fatty amide that is the carboxamide derived from palmitic acid. It has a role as a metabolite. It is functionally related to a hexadecanoic acid.
Source: PubChem
US FDA substance register · UNII QX1MQ82M73 · registered name PALMITAMIDE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name パルミチン酸アミド: 本品は、次の化学式で表される脂肪族アミドである。
Source: JCIA labelling names (Japan)
JCIA labelling name パルミタミド: 本品は、次の化学式で表される脂肪族アミドである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 629-54-9
- EC No.EU chemical inventory number
- 211-095-5
- DTXSIDUS EPA chemical ID
- DTXSID8044707
- DTXCIDUS EPA compound ID
- DTXCID6024707
- IUPAC
- Hexadecanamide
- Molecular formula
- C16H33NO
- Molecular weight
- 255.446 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 107 ℃
- Initial boiling point and range
- 236 ℃
- Flash point
- 191 ℃
- Vapour pressure
- 0.0000023 ㎜Hg
- Water solubility
- 4.1 g/100㎖
- Relative density
- 0.87
- n-Octanol/water partition coefficient (Kow)
- 6.21
- Molecular weight
- 255.45
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
- Hardener1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Efficacy of Topical Application of a Skin Moisturizer Containing Pseudo-Ceramide and a Eucalyptus Leaf Extract on Atopic Dermatitis: A Review · 2024
- Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation · 2024
- The efficacy of synthetic pseudo‐ceramide for dry and rough lips · 2020
- The Efficacy of a Ceramide-based Cream in Mild-to-moderate Atopic Dermatitis. · 2018
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Chinese