N-hexadecanoylglycine is an N-acylglycine in which the acyl group is specified as hexadecanoyl (palmitoyl).
How much products actually contain
No product states its amount yet.
Of the products containing it, 0 list it before the 1% line and 2 after it (usually 1% or less).
Products using this ingredient
2 of 2 confirmed · likeliest to carry enough first
Definition
N-hexadecanoylglycine is an N-acylglycine in which the acyl group is specified as hexadecanoyl (palmitoyl). It has a role as a marine metabolite and a human metabolite. It is a N-acylglycine 16:0 and a fatty amide. It is functionally related to a hexadecanoic acid. It is a conjugate acid of a N-hexadecanoylglycinate.
Source: PubChem
US FDA substance register · UNII M6V3RIU5KI · registered name PALMITOYL GLYCINE · single chemical substance
Cosmetic roles
Safety & regulatory references
Reviewed by CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name パルミトイルグリシン: 本品は、グリシン（＊）のパルミチン酸アミドであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 2441-41-0
- DTXSIDUS EPA chemical ID
- DTXSID40179163
- DTXCIDUS EPA compound ID
- DTXCID70101654
- IUPAC
- N-Hexadecanoylglycine
- Molecular formula
- C18H35NO3
- Molecular weight
- 313.482 g/mol
Measured properties
- Appearance
- Solid · solid
- Colour
- white
- Flammability (solid, gas)
- not flammable
- Vapour pressure
- &, lt, 0.001 ㎩
- n-Octanol/water partition coefficient (Kow)
- 5.85 (log Pow, 25℃)
- Auto-ignition temperature
- 400 ℃
- Molecular weight
- 313.478
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner3
- Cleaning agent2
- Surfactant (surface active agent)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Self-Assembled Palmitoyl-Glycine-Histidine as a Permeation Enhancer for Transdermal Delivery. · 2021
- Combined Use of N-Palmitoyl-Glycine-Histidine Gel and Several Penetration Enhancers on the Skin Permeation and Concentration of Metronidazole · 2018
- Design of a Topically Applied Gel Spray Formulation with Ivermectin Using a Novel Low Molecular Weight Gelling Agent, Palmitoyl-Glycine-Histidine, to Treat Scabies. · 2018
- Two new lipoaminoacids with complementary modes of action: new prospects to fight out against skin aging · 2010
Linked databases 18
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata