- Lines B
- Amount studies used
- as formulated
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
104 products state the amountmedian 0.000001%
- under 0.01% 104
- 0.01–0.1% 0
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 163 list it before the 1% line and 644 after it (usually 1% or less).
Clinical evidence grade by skin concern
- B
- one or two randomised trials
A 2026 meta-analysis found only two trials, so the certainty of the evidence is very low.
Products using this ingredient
12 of 806 confirmed · likeliest to carry enough first · See all 806
AIDAAIDA Pro-Peptide Eye Lift Booster Cream0.00005% stated
ESFOLIOEsfolio Peptide Collagen Toner 180ml0.00001% stated
ESFOLIOEsfolio Peptide Collagen Serum0.00001% stated
ESFOLIOEsfolio Peptide Collagen Cream 70g0.00001% stated
ESFOLIOEsfolio Peptide Collagen Eye Cream 30g0.00001% stated
MEDIPEELMEDIPEEL Peptide Tox Bor Eye Cream 40ml0.00001% stated
MEDIPEELMEDIPEEL Peptide 9 Aqua Essence Facial Cleanser 150ml0.000001% stated
MEDIPEELMEDIPEEL Peptide Tox Bor Cream 50g0.000001% stated
NEOGENNeogen Surmedic+ Azulene Soothing Ampoule 80ml0.00000015% stated
ENOUGH8-Peptide Sensation Pro Balancing Ampoule0.00000005% stated
SOME BY MISOME BY MI Cica Peptide Anti Hair Loss Derma Scalp Tonic 150ml0.00000001% stated
MEDIPEELMEDIPEEL Hyaluron Aqua Peptide 9 Ampoule Eye Patch 1.6g x 60 Sheets0.00000001% stated
Definition
Lysine, synthetic pentapeptide with serine, and threonine, hexadecanoyl derivatives
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report: Safety Assessment of Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4 and Pentapeptide-4 as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name パルミトイルペンタペプチド－４: 本品は、パルミチン酸（＊）とリシン（＊）、セリン（＊）及びトレオニン（＊）残基からなる合成ペンタペプチドとの反応生成物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 214047-00-4
- CAS No.chemical registry number
- 521091-64-5
Related literature
- Frontiers in Skin Rejuvenation: Recent Advances in Anti-Aging Skincare Technologies Based on Proteins, Peptides, and Peptide Derivatives · 2025
- A framework for the safety evaluation of peptides in cosmetics. · 2026
- Constrained Evolutionary Design of Matrixyl Analogs: Balancing Permeability and Functional Preservation Through Computational Optimization · 2026
- The anti-aging effect and mechanism of a compound peptide on sensitive skin · 2026
- Constrained Evolutionary Design of Matrixyl Analogs: Balancing Permeability and Functional Preservation Through Computational Optimization · 2026
Linked databases 9
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Europe PMC 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- Tlooto literature search 2 3
- US Cosmetic Ingredient Review (CIR) 2