Dodecamethylpentasiloxane is an organosiloxane that is pentasiloxane in which all the hydrogens have been replaced by methyl groups.
Definition
Dodecamethylpentasiloxane is an organosiloxane that is pentasiloxane in which all the hydrogens have been replaced by methyl groups. Metabolite observed in cancer metabolism. It has a role as a human metabolite.
Source: PubChem
US FDA substance register · UNII 0QDQ2VQ5YJ · registered name DODECAMETHYLPENTASILOXANE · single chemical substance
Pentasiloxane is the linear siloxane that conforms to the formula.
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 141-63-9
- EC No.EU chemical inventory number
- 205-492-2
- DTXSIDUS EPA chemical ID
- DTXSID1044803
- DTXCIDUS EPA compound ID
- DTXCID9024803
- IUPAC
- Dodecamethylpentasiloxane
- Molecular formula
- C12H36O4Si5
- Molecular weight
- 384.841 g/mol
Measured properties
- Appearance
- Liquid · Liquid, [Merck Index] Colorless odorless liquid, [Acros Organics MSDS]
- Boiling point
- 230 °C · BP: 229 °C at 710 mm Hg
- Melting point
- -80 °C
- Solubility
- In water, 7.04X10-5 mg/L at 25 °C · Soluble in carbon tetrachloride, carbon disulfide
- Density
- 0.8755 g/cu cm at 20 °C
- Stability
- Stable under recommended storage conditions.
- Viscosity
- Maintains about the same viscosity over a wide temperature range · 1.7 cSt
- Melting/freezing point
- -80 ℃
- Initial boiling point and range
- 232 ℃(1013 hPa)
- Flash point
- 79 ℃(101.3 kPa)
- Vapour pressure
- 6 ㎩(25 °C)
- Water solubility
- 0.00007041 ㎎/ℓ
- Relative density
- 0.893
- n-Octanol/water partition coefficient (Kow)
- 9.41
- Auto-ignition temperature
- 350 ℃(101.3 kPa)
- Molecular weight
- 384.93
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Diluent2
- Heat transferring agent1
- Lubricating agent1
- Solvent1
- Intermediate1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OPPTS 870.2400 (Acute Eye Irritation) according to
Source: US EPA CompTox dashboard