Perfluorodecalin is a fluorocarbon that is decalin in which every hydrogen is replaced by fluorine.
Definition
Perfluorodecalin is a fluorocarbon that is decalin in which every hydrogen is replaced by fluorine. Capable of dissolving large quantities of oxygen, it has been used as the basis of an artificial blood substitute. It has a role as a blood substitute and a solvent. It derives from a hydride of a decalin.
Source: PubChem
US FDA substance register · UNII 54A06VV62N · registered name PERFLUNAFENE · single chemical substance
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name パーフルオロデカリン: 本品は、次の化学式で表される脂環式化合物のフッ素誘導体である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 306-94-5
- EC No.EU chemical inventory number
- 206-192-4
- DTXSIDUS EPA chemical ID
- DTXSID0046511
- DTXCIDUS EPA compound ID
- DTXCID8026511
- IUPAC
- Octadecafluorodecahydronaphthalene
- Molecular formula
- C10F18
- Molecular weight
- 462.081 g/mol
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner2
- Solvent2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- A Novel Topical Perfluorodecalin Gel for the Management of Radiotherapy-induced Skin Toxicity: A Prospective Observational Study · 2025
- Perfluorodecalin-based oxygenated emulsion as a topical treatment for chemical burn to the eye · 2022
- The effect of the perfluorodecalin patch on particle emission and skin temperature during laser-induced tattoo removal · 2020
- Perfluorodecalin‐infused patch in picosecond and Q‐switched laser‐assisted tattoo removal: Safety in Fitzpatrick IV–VI skin types · 2018
- Evaluation of a transparent perfluorodecalin‐infused patch as an adjunct to laser‐assisted tattoo removal: A pivotal trial · 2017
Linked databases 17
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Chinese