Phenacetin can cause cancer according to California Labor Code.
How much products actually contain
No product states its amount yet.
Of the products containing it, 0 list it before the 1% line and 2 after it (usually 1% or less).
Products using this ingredient
2 of 2 confirmed · likeliest to carry enough first
Definition
Phenacetin can cause cancer according to California Labor Code.
Source: PubChem
US FDA substance register · UNII ER0CTH01H9 · registered name PHENACETIN · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- ASEAN · China
Source: ASEAN Cosmetic Directive · MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance · priority-management substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 62-44-2
- EC No.EU chemical inventory number
- 200-533-0
- DTXSIDUS EPA chemical ID
- DTXSID1021116
- DTXCIDUS EPA compound ID
- DTXCID001116
- IUPAC
- N-(4-Ethoxyphenyl)acetamide
- Molecular formula
- C10H13NO2
- Molecular weight
- 179.219 g/mol
Measured properties
- Appearance
- Phenacetin is an odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine. · Dry Powder
- Odour
- ODORLESS · odourless
- Boiling point
- Decomposes (NTP, 1992) · 242-245 °C
- Melting point
- 273 to 280 °F (NTP, 1992) · 137.5 °C
- Solubility
- less than 1 mg/mL at 68 °F (NTP, 1992) · 766 mg/L (at 25 °C)
- Stability
- Stable in air.
- pH
- SATURATED SOLN IS NEUTRAL TO LITMUS
- Colour
- colourless
- Melting/freezing point
- 137.5 ℃
- Initial boiling point and range
- 242~245 ℃
- Vapour pressure
- 0.000000692 ㎜Hg(25℃)
- Water solubility
- 766 ㎎/ℓ(25℃)
- n-Octanol/water partition coefficient (Kow)
- 1.58
- Molecular weight
- 179.22
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Stabilizing agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Classification not possible
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - SkinSens1
Skin Sensitization · QSAR Predicted - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- [Experimental study of the carcinogenicity of phenacetin]. · 1986
- Analytical Method Development of Benzisothiazolinone, a Biocide, Using LC–MS/MS and a Pharmacokinetic Application in Rat Biological Matrices · 2023
- Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities. · 2015
- A case of levetiracetam induced bullous pemphigoid · 2013
- Carcinogenicity of phenacetin: Long‐term feeding study in B6C3F1 mice · 1982
Linked databases 23
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- IARC carcinogen classification
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · English · Japanese · Chinese