Phenethyl isothiocyanate is an isothiocyanate having a phenethyl group attached to the nitrogen.
定義
Phenethyl isothiocyanate is an isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties. It has a role as a metabolite, an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor and an antineoplastic agent.
出典: PubChem
米国FDA 物質登録 · UNII 6U7TFK75KV · 登録名 PHENETHYL ISOTHIOCYANATE · 単一の化学物質
化粧品での役割
製品に香りをつけるPERFUMING
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
PHENETHYL ISOTHIOCYANATEINCIBenzene, (2-isothiocyanatoethyl)-別名
- CAS No.化学物質登録番号
- 2257-09-2
- EC No.EU化学物質目録番号
- 218-855-5
- DTXSID米国EPA化学物質番号
- DTXSID5021120
- DTXCID米国EPA化合物番号
- DTXCID901120
- IUPAC
- (2-Isothiocyanatoethyl)benzene
- 分子式
- C9H9NS
- 分子量
- 163.24 g/mol
測定された物性
- 性状
- Colorless to pale yellow liquid, [Merck Index] Clear colorless liquid, [Sigma-Aldrich MSDS] · Nearly Colourless liquid, Strong green irritating aroma
- 沸点
- 139.00 to 140.00 °C. @ 11.00 mm Hg · 139-140 °C
- 溶解性
- 110 mg/L @ 20 °C (exp) · Insoluble in water, Soluble in triacetin and heptane
- 密度
- 1.087-1.097
物質そのものを測定した値で、原料商品の規格ではありません。
出典: PubChem
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品4件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Flavouring and nutrient2
- Fragrance2
出典: 米国EPA CompTox
関連文献
- Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. · 2013
- Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells · 2024
- Phenethyl Isothiocyanate-Containing Carbomer Gel for Use against Squamous Cell Carcinoma · 2021
- Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways · 2014
- Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models · 2012