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Ingredientes

Diccionario de ingredientes

PHENYL METHYL PYRAZOLONE

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

Estructura molecular

Definición

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. It has a role as an antioxidant and a radical scavenger.

Fuente: PubChem

Registro de sustancias de la FDA (EE. UU.) · UNII S798V6YJRP · nombre registrado Edaravone · sustancia química única

Fuente: Identificador único de ingredientes de la FDA (UNII)

Funciones cosméticas

Tiñe el cabelloHAIR DYEING

Referencias de seguridad y regulación

Prohibido
Corea del Sur
Restringido
Reino Unido · Taiwán

Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)

ASEAN

  • Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
  • Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25 % The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

China

  • Concentración máxima : 0.25%

Unión Europea

  • Product Type, body parts : Hair dye subtance in oxidative hair dye products
  • Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25%.
  • Wording of conditions of use and warnings : To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.

Fuente: Información regulatoria cosmética del MFDS (Corea)

Sin clasificación en la lista GHS de sustancias tóxicas de Corea · sustancia química existente

Fuente: Registro GHS de sustancias tóxicas de Corea (NIER)

Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 228 · se aplica a Hair dye subtance in oxidative hair dye products

Fuente: Sustancias restringidas UE (anexo III)

Restriction III/228 · SCCS opinion: Opinion on Phenyl methyl pyrazolone

Fuente: Lista de ingredientes CosIng (UE)

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Reviewed by CIR: Final Report on the Safety Assessment of Phenyl Methyl Pyrazolone

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Más datos: nombres, identificadores, propiedades, ensayos y literatura

Nombres e identificadores

PHENYL METHYL PYRAZOLONEINCI페닐메틸피라졸론Nombre en etiquetas coreanas (estándar MFDS)3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-Sinónimo
CAS No.número de registro químico
89-25-8
EC No.número de inventario químico de la UE
201-891-0
DTXSIDidentificador químico de la EPA (EE. UU.)
DTXSID9021130
DTXCIDidentificador de compuesto de la EPA (EE. UU.)
DTXCID201130
IUPAC
5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Fórmula molecular
C10H10N2O
Peso molecular
174.203 g/mol

Propiedades medidas

Aspecto
1-phenyl-3-methyl-5-pyrazolone appears as white to off-white powder or crystals. (NTP, 1992) · White solid, [Merck Index] Light yellow odorless powder, [Alfa Aesar MSDS]
Punto de ebullición
549 °F at 105 mmHg (NTP, 1992) · 287
Punto de fusión
261 to 266 °F (NTP, 1992) · 129.7
Solubilidad
less than 1 mg/mL at 73 °F (NTP, 1992) · SOL IN HOT WATER & HOT ALCOHOL, SLIGHTLY SOL IN BENZENE, INSOL IN PETROLEUM ETHER
Constante de disociación
7.0
Color
blanco
pH
4 (4 - 4.4)
Punto de fusión/congelación
129 ℃
Punto inicial e intervalo de ebullición
191 ℃(@ 17 mmHg)
Punto de inflamación
155 ℃
Inflamabilidad (sólido, gas)
inflamable
Presión de vapor
0.01 ㎜Hg
Solubilidad en agua
3300 ㎎/ℓ (at 20℃)
Densidad de vapor
6.01
Densidad relativa
1.12 (at 20℃)
Coeficiente de reparto n-octanol/agua (Kow)
2.56 (est.)
Temperatura de autoignición
490 ℃ (at 20℃)
Peso molecular
174.2

Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.

Fuente: PubChem · Fichas de datos de seguridad de KOSHA (Corea)

Para qué lo usan los productos

Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.

  • Dye3

Fuente: Panel CompTox de la EPA

Estudios de irritación y sensibilización

Constan 5 estudios en piel y 4 en ojos.

Clasificado como moderado2Clasificado como bajo2

Los estudios no coinciden (la conclusión más frecuente reúne el 50%), así que no demuestran que el ingrediente sea irritante. Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.

Ver los 9 estudios
  • Low to Moderate Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) The identity of the test substance was not sufficiently documented. Only a summary test report was available, there was no raw data. However, the study was conducted under FDA test protocols. Appropriate dose level was used. The scoring system deviated slighty from the current OECD protocol. Control analysis was performed. Restriction for reliability was due to the age of the study (1980). equivalent or similar to
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) Adopted : 17 July 1992, Buehler test (3 applications)
  • Low to Moderate Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) Adopted : 24th April 2002
  • Ambiguous
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 12 May 1981 according to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
  • Ambiguous
    eye irritation: in vitro / ex vivo · Screening · other guideline: Journal Officiel de la Republique Francaise (JORF) No. 300, 28 November 1996, page 19137 REACh regulation recommends ECVAM protocols DB-ALM No. 47, January 1992 and DB-ALM No. 96, July 1994. equivalent or similar to
  • Ambiguous
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Dated February 24th 1987 equivalent or similar to

Fuente: Panel CompTox de la EPA

Literatura relacionada

Bases de datos vinculadas 29