この成分は何ですか?

이 원료는 다음의 구조를 갖는 헤테로사이클릭아민이다.

成分辞典

PHENYL METHYL PYRAZOLONE

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

定義

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. It has a role as an antioxidant and a radical scavenger.

出典: PubChem

米国FDA 物質登録 · UNII S798V6YJRP · 登録名 Edaravone · 単一の化学物質

出典: 米国FDA 物質識別番号（UNII）

化粧品での役割

髪を染めるHAIR DYEING

安全性・規制情報

禁止: 韓国
制限: イギリス

出典: 韓国食薬処化粧品規制情報 · ASEAN 化粧品指令 · EU 化粧品規則 · 台湾FDA 化粧品成分 · 台湾FDA 化粧品規制 · 英国化粧品規則

ASEAN

Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25 % The direction for use “wear suitable gloves” must be included in label or leaflet text.
Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

台湾

※ 染髮產品之限量標準：係指該成分依產品使用說明書混合後之最高允許使用量。
※ 化粧品之外包裝或容器，應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者，應於標籤、仿單或以其他方式刊載之。
※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
※ 化粧品宣稱效能者，須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
用途 : 使用限制
最大配合量 : 氧化性染髮產品 : 0.25%

中国

最大配合量 : 0.25%

欧州連合

Product Type, body parts : Hair dye subtance in oxidative hair dye products
Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25%.
Wording of conditions of use and warnings : To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.

出典: 韓国食薬処化粧品規制情報

韓国の有害物質GHS分類なし · 既存化学物質

出典: 韓国有害物質GHS情報（環境公団）

EU化粧品規則附属書III（制限物質）第228項 · 適用 Hair dye subtance in oxidative hair dye products

出典: EU 制限成分（附属書III）

Restriction III/228 · SCCS opinion: Opinion on Phenyl methyl pyrazolone

出典: EU CosIng 成分リスト

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

出典: 米国CIR 安全性評価

Reviewed by CIR: Final Report on the Safety Assessment of Phenyl Methyl Pyrazolone

出典: 米国CIR 安全性評価

詳しい資料 — 表示名・識別番号・物性・試験記録・文献

別名・識別情報

PHENYL METHYL PYRAZOLONEINCI페닐메틸피라졸론韓国の表示名（食薬処標準名）3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-別名

CAS No.化学物質登録番号: 89-25-8
EC No.EU化学物質目録番号: 201-891-0
DTXSID米国EPA化学物質番号: DTXSID9021130
DTXCID米国EPA化合物番号: DTXCID201130

IUPAC: 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
分子式: C10H10N2O
分子量: 174.203 g/mol

測定された物性

性状: 1-phenyl-3-methyl-5-pyrazolone appears as white to off-white powder or crystals. (NTP, 1992) · White solid, [Merck Index] Light yellow odorless powder, [Alfa Aesar MSDS]
沸点: 549 °F at 105 mmHg (NTP, 1992) · 287
融点: 261 to 266 °F (NTP, 1992) · 129.7
溶解性: less than 1 mg/mL at 73 °F (NTP, 1992) · SOL IN HOT WATER & HOT ALCOHOL, SLIGHTLY SOL IN BENZENE, INSOL IN PETROLEUM ETHER
解離定数: 7.0
色: 白色
pH: 4 (4 - 4.4)
融点・凝固点: 129 ℃
初留点および沸点範囲: 191 ℃(@ 17 mmHg)
引火点: 155 ℃
可燃性（固体、気体）: 引火性
蒸気圧: 0.01 ㎜Hg
溶解度: 3300 ㎎/ℓ (at 20℃)
蒸気密度: 6.01
比重: 1.12 (at 20℃)
n-オクタノール/水分配係数（Kow）: 2.56 (推定値)
自然発火温度: 490 ℃ (at 20℃)
分子量: 174.2

物質そのものを測定した値です。安全保健公団（KOSHA）の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。

出典: PubChem · 韓国安全保健公団 SDS

製品が実際に使っている用途

米国EPAにこの成分を届け出た製品3件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。

Dye3

出典: 米国EPA CompTox

刺激・感作試験の記録

皮膚試験5件・眼試験4件の記録があります。

中程度と分類2件低いと分類2件

試験ごとに結論が分かれています（最も多い結論の割合 50%）。この成分が刺激性だとは言い切れないということです。原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。

試験9件をすべて見る

Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) The identity of the test substance was not sufficiently documented. Only a summary test report was available, there was no raw data. However, the study was conducted under FDA test protocols. Appropriate dose level was used. The scoring system deviated slighty from the current OECD protocol. Control analysis was performed. Restriction for reliability was due to the age of the study (1980). equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) Adopted : 17 July 1992, Buehler test (3 applications)
Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) Adopted : 24th April 2002
Ambiguous
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 12 May 1981 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: Journal Officiel de la Republique Francaise (JORF) No. 300, 28 November 1996, page 19137 REACh regulation recommends ECVAM protocols DB-ALM No. 47, January 1992 and DB-ALM No. 96, July 1994. equivalent or similar to
Ambiguous
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Dated February 24th 1987 equivalent or similar to