Ingredient Dictionary

PHLORIDZIN

Definition

Phlorhizin

US FDA substance register · UNII CU9S17279X · registered name PHLORIZIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

PHLORIDZININCI

CAS No.chemical registry number: 60-81-1
EC No.EU chemical inventory number: 200-487-1
DTXSIDUS EPA chemical ID: DTXSID3075339
DTXCIDUS EPA compound ID: DTXCID1042738

IUPAC: 3,5-Dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside
Molecular formula: C21H24O10
Molecular weight: 436.413 g/mol

Measured properties

Melting/freezing point: 110 ℃(est.)
Initial boiling point and range: 596.94 ℃(est.)
Flash point: 270.7 ℃(est.)
Vapour pressure: 0.0000000000000000316 ㎜Hg (at 25C , est.)
Water solubility: 1000 ㎎/ℓ (at 22C)
n-Octanol/water partition coefficient (Kow): 0.720 (est.)
Molecular weight: 344.32

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 2 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
Corrosive or Irritation Persists for > 21 days
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to EU method B.48 (Isolated chicken eye test method for identifying occular corrosives and severe irritants) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to