Ingredient Dictionary

PHLOROGLUCINOL

Phloroglucinol is a benzenetriol with hydroxy groups at position 1, 3 and 5.

Definition

Phloroglucinol is a benzenetriol with hydroxy groups at position 1, 3 and 5. It has a role as an algal metabolite. It is a phenolic donor and a benzenetriol.

Source: PubChem

US FDA substance register · UNII DHD7FFG6YS · registered name Phloroglucinol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1253

Source: EU prohibited substances (Annex II)

Restriction II/1253

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Phloroglucinol

Source: US Cosmetic Ingredient Review (CIR)

CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

PHLOROGLUCINOLINCI플로로글루시놀Korean label name (MFDS standard)1,3,5-BenzenetriolSynonym

CAS No.chemical registry number: 108-73-6
EC No.EU chemical inventory number: 203-611-2
DTXSIDUS EPA chemical ID: DTXSID9048354
DTXCIDUS EPA compound ID: DTXCID0028329

IUPAC: Benzene-1,3,5-triol
Molecular formula: C6H6O3
Molecular weight: 126.111 g/mol

Measured properties

Appearance: solid
Colour: white
Odour: odourless
Melting/freezing point: 219 ℃
Water solubility: 10.6 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 0.55 (log Pow, 25℃)

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
SkinSens1
Skin Sensitization · QSAR Predicted
Category 6.4A (Category 2A)
Eye Irritation · Read Across