Definition
US FDA substance register · UNII 306P37319L · registered name PHOSPHONOBUTANETRICARBOXYLIC ACID · single chemical substance
Cosmetic roles
Keeps pH steadyBUFFERINGPrevents corrosion of packaging and equipmentANTICORROSIVEBinds metal ions to prevent spoilageCHELATING
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
PHOSPHONOBUTANETRICARBOXYLIC ACIDINCI포스포노부탄트라이카복실릭애씨드Korean label name (MFDS standard)1,2,4-Butanetricarboxylic acid, 2-phosphono-Synonym
- CAS No.chemical registry number
- 37971-36-1
- EC No.EU chemical inventory number
- 253-733-5
- DTXSIDUS EPA chemical ID
- DTXSID4027999
- DTXCIDUS EPA compound ID
- DTXCID807999
- IUPAC
- 2-Phosphonobutane-1,2,4-tricarboxylic acid
- Molecular formula
- C7H11O9P
- Molecular weight
- 270.13 g/mol
Measured properties
- Appearance
- Liquid · Produced as a solid, Available as aqeous solution, [eChemPortal: SIDSUNEP] Dark straw-colored liquid, [MSDSonline]
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 20 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Chelating agent8
- Corrosion inhibitor5
- Dispersing agent2
- Anti-scaling agent2
- pH regulating agent1
- Flotation agent1
- Processing aids not otherwise specified1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 3 eye studies are on record.
Classed as low5
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to other guideline: EG-guideline 83/467 according to - Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: EU Test Method B.46 according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) The study was originally done according to EG-guideline 83/467 equivalent or similar to other guideline: EG-guideline 83/467 equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) It should be mentioned that at that time (1971), there was no guideline available equivalent or similar to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to other guideline: EG-guideline 83/467 according to - Severe Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: ICCVAM Test Method Evaluation Report: Appendix G: ICCVAM Recommended Protocol for Future Studies Using the Hen's Egg Test-Chorionallantoic Membrane (HET-CAM) Test method, November 2006 according to - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Linked databases 12
- Australian Industrial Chemicals Inventory (AICIS)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata