定义
美国FDA 物质登记 · UNII 306P37319L · 登记名称 PHOSPHONOBUTANETRICARBOXYLIC ACID · 单一化学物质
化妆品中的作用
稳定 pHBUFFERING防止容器和设备腐蚀ANTICORROSIVE螯合金属离子防止变质CHELATING
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
PHOSPHONOBUTANETRICARBOXYLIC ACIDINCI포스포노부탄트라이카복실릭애씨드韩国标示名称（食药处标准名）1,2,4-Butanetricarboxylic acid, 2-phosphono-同义名
- CAS No.化学物质登记号
- 37971-36-1
- EC No.欧盟化学品目录编号
- 253-733-5
- DTXSID美国EPA化学品编号
- DTXSID4027999
- DTXCID美国EPA化合物编号
- DTXCID807999
- IUPAC
- 2-Phosphonobutane-1,2,4-tricarboxylic acid
- 分子式
- C7H11O9P
- 分子量
- 270.13 g/mol
实测物性
- 性状
- Liquid · Produced as a solid, Available as aqeous solution, [eChemPortal: SIDSUNEP] Dark straw-colored liquid, [MSDSonline]
这是对物质本身测得的数值，并非原料商品的规格。
来源: PubChem
产品实际使用的用途
这是向美国 EPA 申报含该成分的 20 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Chelating agent8
- Corrosion inhibitor5
- Dispersing agent2
- Anti-scaling agent2
- pH regulating agent1
- Flotation agent1
- Processing aids not otherwise specified1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 6 项、眼部试验 3 项。
归类为低5 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 9 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to other guideline: EG-guideline 83/467 according to - Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: EU Test Method B.46 according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) The study was originally done according to EG-guideline 83/467 equivalent or similar to other guideline: EG-guideline 83/467 equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) It should be mentioned that at that time (1971), there was no guideline available equivalent or similar to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to other guideline: EG-guideline 83/467 according to - Severe Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: ICCVAM Test Method Evaluation Report: Appendix G: ICCVAM Recommended Protocol for Future Studies Using the Hen's Egg Test-Chorionallantoic Membrane (HET-CAM) Test method, November 2006 according to - Category 8.3A (Category 1)
Eye Irritation · Read Across
来源: 美国EPA CompTox