Ingredient Dictionary

PHTHALIC ANHYDRIDE

Phthalic anhydride is the cyclic dicarboxylic anhydride that is the anhydride of phthalic acid.

Definition

Phthalic anhydride is the cyclic dicarboxylic anhydride that is the anhydride of phthalic acid. It has a role as an allergen. It is a cyclic dicarboxylic anhydride and a member of 2-benzofurans.

Source: PubChem

US FDA substance register · UNII UVL263I5BJ · registered name Phthalic anhydride · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Phthalic Anhydride is the organic compound that conforms to the formula.

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Banned: Taiwan

Source: MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

PHTHALIC ANHYDRIDEINCI프탈릭안하이드라이드Korean label name (MFDS standard)1,3-IsobenzofurandioneSynonym

CAS No.chemical registry number: 85-44-9
EC No.EU chemical inventory number: 201-607-5
DTXSIDUS EPA chemical ID: DTXSID2021159
DTXCIDUS EPA compound ID: DTXCID401159

IUPAC: 2-Benzofuran-1,3-dione
Molecular formula: C8H4O3
Molecular weight: 148.117 g/mol

Measured properties

Appearance: solid
Odour threshold: (0.32-0.72 ㎎/㎥)
Melting/freezing point: 131.4 ℃
Initial boiling point and range: 285.3 ℃
Flash point: 152 ℃
Upper/lower flammability or explosive limits: 10.4 / 1.7 %
Vapour pressure: 0.000517 ㎜Hg (25℃)
Water solubility: 0.62 g/100㎖ (25℃)
Vapour density: 6.6
Relative density: 1.53
n-Octanol/water partition coefficient (Kow): 1.6
Auto-ignition temperature: 570 ℃
Decomposition temperature: -3259 (J/kmol)
Viscosity: 1190000 (155℃)
Molecular weight: 148.116

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 25 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Plasticizer4
Chemical reaction regulator4
Monomers3
Polymerization promoter2
Intermediate2
Solvent2
Processing aids not otherwise specified1
Ion exchange agent1

6 other uses

Pigment1
Hardener1
Flame retardant1
No specific technical function1
Elasticizer1
Surface modifier1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

12 skin studies and 5 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 17 studies

Not classified
Skin Irritation · Screening
Category 1
Skin Sensitization · Screening
Skin sensitization - Category 1A
Skin Sensitization · Screening
Skin Irrit. 2
Skin Irritation · Authoritative
Skin Sens. 1
Skin Sensitization · Authoritative
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Category 6.3A (Category 2)
Skin Irritation · Read Across
Skin Sens. 1
Skin Sensitization · Screening
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Skin Irrit. 2
Skin Irritation · Screening
Category 2A
Eye Irritation · Screening
Eye Dam. 1
Eye Irritation · Authoritative
Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Eye Dam. 1
Eye Irritation · Screening