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Ingredient Dictionary

PICRAMIC ACID

Korean limit
0.6%
Molecular structure

Definition

US FDA substance register · UNII 5VDQ7GK8L3 · registered name PICRAMIC ACID · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Restricted
South Korea · Taiwan

Source: MFDS (Korea) cosmetic regulatory information

ASEAN

  • Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
  • Maximum authorised concentration in the finished cosmetic product : (b) 0.6%
  • Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.6 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows

European Union

  • Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
  • Maximum concentration in ready for use preparation : (b) 0.6 %
  • Other : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,6 %
  • Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Picramic acid and sodium picramate

Source: EU CosIng ingredient list

Reviewed by CIR: Amended Safety Assessment of Sodium Picramate and Picramic Acid

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

PICRAMIC ACIDINCI피크라민산Korean label name (MFDS standard)Phenol, 2-amino-4,6-dinitro-Synonym
CAS No.chemical registry number
96-91-3
EC No.EU chemical inventory number
202-544-6
DTXSIDUS EPA chemical ID
DTXSID5024479
DTXCIDUS EPA compound ID
DTXCID904479
IUPAC
2-Amino-4,6-dinitrophenol
Molecular formula
C6H5N3O5
Molecular weight
199.122 g/mol

Measured properties

Appearance
2-amino-4,6-dinitrophenol, wetted with not less than 20% water appears as dark red needles or prisms. Red crystals. Water insoluble. Explosive in the dry state but desensitized by wetting. Easily ignited and once ignited burn readily. · 2-amino-4,6-dinitrophenol appears as dark red needles or prisms. Red crystals. Water insoluble. Explosive in the dry state but desensitized by wetting. Easily ignited and once ignited burn readily.
Melting point
336 °F (NTP, 1992) · 169 °C
Solubility
less than 1 mg/mL at 68.9 °F (NTP, 1992) · @ 22-25 °C, 0.065 g dissolves in 100 ml H2O
n-Octanol/water partition coefficient (Kow)
0.93
Molecular weight
192.12 (HSDB)

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Dye1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 1 eye studies are on record.

Classed as highly irritating3Classed as low1

The study conclusions largely agree (75%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies
  • High Frequency of Sensitization
    skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline:
  • Classification not possible
    Skin Irritation · Screening
  • Classification not possible
    Skin Sensitization · Screening
  • High Frequency of Sensitization
    skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as below
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · other guideline: according to
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • Classification not possible
    Eye Irritation · Screening

Source: US EPA CompTox dashboard

Related literature

Linked databases 20

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