- Límite en Corea
- 0.6%
Definición
Registro de sustancias de la FDA (EE. UU.) · UNII 5VDQ7GK8L3 · nombre registrado PICRAMIC ACID · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Restringido
- Corea del Sur · Taiwán
Fuente: Información regulatoria cosmética del MFDS (Corea)
ASEAN
- Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Maximum authorised concentration in the finished cosmetic product : (b) 0.6%
- Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.6 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows
Unión Europea
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Maximum concentration in ready for use preparation : (b) 0.6 %
- Other : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,6 %
- Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.â€
Fuente: Información regulatoria cosmética del MFDS (Corea)
Sin clasificación en la lista GHS de sustancias tóxicas de Corea · sustancia química existente
Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Picramic acid and sodium picramate
Reviewed by CIR: Amended Safety Assessment of Sodium Picramate and Picramic Acid
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres e identificadores
- CAS No.número de registro químico
- 96-91-3
- EC No.número de inventario químico de la UE
- 202-544-6
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID5024479
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID904479
- IUPAC
- 2-Amino-4,6-dinitrophenol
- Fórmula molecular
- C6H5N3O5
- Peso molecular
- 199.122 g/mol
Propiedades medidas
- Aspecto
- 2-amino-4,6-dinitrophenol, wetted with not less than 20% water appears as dark red needles or prisms. Red crystals. Water insoluble. Explosive in the dry state but desensitized by wetting. Easily ignited and once ignited burn readily. · 2-amino-4,6-dinitrophenol appears as dark red needles or prisms. Red crystals. Water insoluble. Explosive in the dry state but desensitized by wetting. Easily ignited and once ignited burn readily.
- Punto de fusión
- 336 °F (NTP, 1992) · 169 °C
- Solubilidad
- less than 1 mg/mL at 68.9 °F (NTP, 1992) · @ 22-25 °C, 0.065 g dissolves in 100 ml H2O
- Coeficiente de reparto n-octanol/agua (Kow)
- 0.93
- Peso molecular
- 192.12 (HSDB)
Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.
Fuente: PubChem · Fichas de datos de seguridad de KOSHA (Corea)
Para qué lo usan los productos
Usos de los 1 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Dye1
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 6 estudios en piel y 1 en ojos.
Las conclusiones de los estudios coinciden en general (75%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 7 estudios
- High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: - Classification not possible
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as below - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: according to - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Classification not possible
Eye Irritation · Screening
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Detection of picramic acid and picramate in henné products by NMR Spectroscopy · 2018
- Amended safety assessment of sodium picramate and picramic acid. · 2009
- Final Report on the Safety Assessment of Sodium Picramate · 1992
- Bioconcentration and metabolism of picric acid (2,4,6-trinitrophenol) and picramic acid (2-amino-4,6-dinitrophenol) in rainbow trout Salmo gairdneri. · 1984
Bases de datos vinculadas 20
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4
- ChEMBL
- Cosmetic Ingredient Review (CIR, EE. UU.) 2
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Fichas de datos de seguridad de KOSHA (Corea)
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- NIST Chemistry WebBook
- Panel CompTox de la EPA 2
- PubChem
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Registro GHS de sustancias tóxicas de Corea (NIER)
- Wikidata
- Wikipedia · inglés · chino