What is this ingredient?

미국 FDA 물질 등록 · UNII N52TUS5TRY · 등록명 BENZIDINE YELLOW · 단일 화학물질

All ingredients

Ingredient Dictionary

PIGMENT YELLOW 12

Definition

US FDA substance register · UNII N52TUS5TRY · registered name BENZIDINE YELLOW · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom
Restricted: Japan

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1263

Source: EU prohibited substances (Annex II)

Restriction II/1263

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name 黄２０５: 本品は、昭和41年厚生省令第30号に示される黄色205号である。

Source: JCIA labelling names (Japan)

Names & identifiers

PIGMENT YELLOW 12INCI피그먼트황색12호Korean label name (MFDS standard)Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenyl-Synonym黄２０５Japanese labelling name

CAS No.chemical registry number: 6358-85-6
EC No.EU chemical inventory number: 228-787-8
DTXSIDUS EPA chemical ID: DTXSID1021451
DTXCIDUS EPA compound ID: DTXCID30809927

IUPAC: 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl)]bis(3-oxo-N-phenylbutanamide)
Molecular formula: C32H26Cl2N6O4
Molecular weight: 629.5 g/mol

Measured properties

Appearance: Diarylanilide yellow is an odorless fine yellow powder. (NTP, 1992) · Liquid, CBI, Dry Powder, Wet Solid
Melting point: 593 to 608 °F (decomposes) (NTP, 1992) · 320 °C
Solubility: less than 1 mg/mL at 72 °F (NTP, 1992)
Density: 1.22 (NTP, 1992) - Denser than water, will sink
Melting/freezing point: 320 ℃
Vapour pressure: (9.04E-22 mmHg/25°C)
Water solubility: 0.0000361 ㎎/ℓ(@ 25 ℃, est.)
Vapour density: 21.7
Relative density: 1.4
n-Octanol/water partition coefficient (Kow): 6.8 (est.)
Molecular weight: 629.54

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 21 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pigment16
Dye3
Processing aids not otherwise specified2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 7 eye studies are on record.

Classed as low15

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 15 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: method given in the "Hazardous Substances Regulations" under the U.S. Federal Hazardous Substances Labelling Act Sect. 191.11 (February 1965) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO). according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: FDA-guidelines according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg., Vol. 37, No. 38, 1972) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: procedure set out in the "Hazardous Substances Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act Sect. 191.12 (February 1965), conducted with slight modification. according to