定义
美国FDA 物质登记 · UNII N52TUS5TRY · 登记名称 BENZIDINE YELLOW · 单一化学物质
化妆品中的作用
染发HAIR DYEING
安全与法规参考
- 禁用
- 阿根廷 · 巴西 · 东盟 · 韩国 · 欧盟 · 台湾 · 英国 · 中国
- 限用
- 日本
来源: 东盟化妆品指令 · 欧盟化妆品法规 · 韩国食药处 化妆品法规信息 · 台湾FDA 化妆品成分 · 英国化妆品法规
未列入韩国有毒物质 GHS 分类 · 现有化学物质
欧盟化妆品法规 附录II（禁用物质） 第1263项
来源: 欧盟禁用成分（附录II）
Restriction II/1263
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 黄２０５: 本品は、昭和41年厚生省令第30号に示される黄色205号である。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
PIGMENT YELLOW 12INCI피그먼트황색12호韩国标示名称（食药处标准名）Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenyl-同义名黄２０５日本标示名称
- CAS No.化学物质登记号
- 6358-85-6
- EC No.欧盟化学品目录编号
- 228-787-8
- DTXSID美国EPA化学品编号
- DTXSID1021451
- DTXCID美国EPA化合物编号
- DTXCID30809927
- IUPAC
- 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl)]bis(3-oxo-N-phenylbutanamide)
- 分子式
- C32H26Cl2N6O4
- 分子量
- 629.5 g/mol
实测物性
- 性状
- Diarylanilide yellow is an odorless fine yellow powder. (NTP, 1992) · Liquid, CBI, Dry Powder, Wet Solid
- 熔点
- 593 to 608 °F (decomposes) (NTP, 1992) · 320 °C
- 溶解性
- less than 1 mg/mL at 72 °F (NTP, 1992)
- 密度
- 1.22 (NTP, 1992) - Denser than water, will sink
- 熔点/凝固点
- 320 ℃
- 蒸气压
- (9.04E-22 mmHg/25°C)
- 溶解度
- 0.0000361 ㎎/ℓ(@ 25 ℃, 估算值)
- 蒸气密度
- 21.7
- 比重
- 1.4
- 正辛醇/水分配系数（Kow）
- 6.8 (估算值)
- 分子量
- 629.54
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 21 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Pigment16
- Dye3
- Processing aids not otherwise specified2
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 8 项、眼部试验 7 项。
归类为低15 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 15 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: method given in the "Hazardous Substances Regulations" under the U.S. Federal Hazardous Substances Labelling Act Sect. 191.11 (February 1965) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO). according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: FDA-guidelines according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg., Vol. 37, No. 38, 1972) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: procedure set out in the "Hazardous Substances Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act Sect. 191.12 (February 1965), conducted with slight modification. according to
来源: 美国EPA CompTox