Ingredient Dictionary

PIPERONYL BUTOXIDE

Piperonyl butoxide is a member of benzodioxoles.

Definition

Piperonyl butoxide is a member of benzodioxoles. It has a role as a pesticide synergist.

Source: PubChem

US FDA substance register · UNII LWK91TU9AH · registered name PIPERONYL BUTOXIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Piperonyl Butoxide is the organic compound that conforms to the formula:

Cosmetic roles

Protects skin from outside irritantsSKIN PROTECTING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

PIPERONYL BUTOXIDEINCI피페로닐부톡사이드Korean label name (MFDS standard)1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-Synonym

CAS No.chemical registry number: 51-03-6
EC No.EU chemical inventory number: 200-076-7
DTXSIDUS EPA chemical ID: DTXSID1021166
DTXCIDUS EPA compound ID: DTXCID501166

IUPAC: 5-{[2-(2-Butoxyethoxy)ethoxy]methyl}-6-propyl-2H-1,3-benzodioxole
Molecular formula: C19H30O5
Molecular weight: 338.444 g/mol

Measured properties

Appearance: Piperonyl butoxide is a pale yellow to light brown liquid with a mild odor and a faint bitter taste. (NTP, 1992) · Liquid
Odour: ODORLESS · Mild odor
Boiling point: 356 °F at 1 mmHg (NTP, 1992) · 180 °C at 1 mm Hg /Technical/
Solubility: less than 1 mg/mL at 64 °F (NTP, 1992) · Miscible with methanol, ethanol, benzene, Freons, Geons, petroleum oils, and other organic solvents
Density: 1.04 to 1.07 at 68 °F (NTP, 1992) · 1.06 at 20 °C
Stability: Very stable to hydrolysis and uv irradiation. · Stable at 100 °C, thin films of commercial grade material are stable to intense fluorescent light for up to 7 days
Viscosity: 40 cP at 25 °C
Melting/freezing point: &amp, lt, 25 ℃
Initial boiling point and range: 180 ℃(at 1 mmHg)
Flash point: 171 ℃((CC))
Vapour pressure: (2.6E-007mmHg at 25 ℃ (est.))
Relative density: 1.04-1.07 (at 20 C)
n-Octanol/water partition coefficient (Kow): 4.75
Molecular weight: 338.43

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 142 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Biocide140
Humectant1
Pharmaceutical (EPA)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Category 6.3B (Category 3)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to