Piperonylic acid is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5.
Definition
Piperonylic acid is a member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties. It has a role as an EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor, an antifungal agent, a vulnerary and a plant metabolite. It is a monocarboxylic acid, an aromatic carboxylic acid and a member of benzodioxoles. It is a conjugate acid of a piperonylate.
Source: PubChem
US FDA substance register · UNII QX3V1NO0KH · registered name PIPERONYLIC ACID · single chemical substance
Piperonylic Acid is the organic compound that conforms to the formula.
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ピペロニル酸: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 94-53-1
- EC No.EU chemical inventory number
- 202-342-8
- DTXSIDUS EPA chemical ID
- DTXSID6059104
- DTXCIDUS EPA compound ID
- DTXCID7048902
- IUPAC
- 2H-1,3-Benzodioxole-5-carboxylic acid
- Molecular formula
- C8H6O4
- Molecular weight
- 166.132 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Humectant1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Green Synthesis of Zinc Oxide Nanoparticles Using Piperonylic Acid: Characterization and Antibacterial Activity · 2026
- Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway · 2024
- Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition · 2021
- Piperonylic acid stimulates keratinocyte growth and survival by activating epidermal growth factor receptor (EGFR) · 2018
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata