What is this ingredient?

미국 FDA 물질 등록 · UNII A4V5C6R9FB · 등록명 PIROCTONE OLAMINE · 단일 화학물질

All ingredients

Ingredient Dictionary

PIROCTONE OLAMINE

How much products actually contain

No product states its amount yet.

Of the products containing it, 32 list it before the 1% line and 74 after it (usually 1% or less).

Products using this ingredient

12 of 105 confirmed · likeliest to carry enough first · See all 105

Definition

US FDA substance register · UNII A4V5C6R9FB · registered name PIROCTONE OLAMINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Piroctone Olamine is the amine salt that conforms to the formula:

Cosmetic roles

Acts on seborrheic flaking and dandruffANTI-SEBORRHEICStops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Restricted or banned: China · South Korea · Taiwan
Allowed preservative: Taiwan

Source: MFDS (Korea) cosmetic regulatory information · Japan Standards for Cosmetics · Taiwan FDA cosmetic ingredients

Argentina · Brazil

Maximum concentration permitted at final product : Under maximum secondary amine: 0.5%
Other limitations and requirements : No use with nitrosating systems. Minimum 99% -Pureza. Maximum -Tenor of secondary amines in raw materials 0.5%. Maximum nitrosamine -Tenor: 50 ug / kg. -Envasar / Nitrite - free store in containers.

ASEAN

Maximum authorised concentration in the finished cosmetic product : Maximum secondary amine content: 0.5%
Other limitations and requirements : • Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content: 0.5% (applies to raw materials) • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers

Japan

Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.05 g
Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.05 g

European Union

Maximum concentration in ready for use preparation : Maximum secondary amine content: 0.5%
Other : - Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers
Product Type, body parts : a) Rinse-off products b) Other products
Maximum concentration in ready for use preparation : a) 1.0% b) '0.5%

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction III/61 V/35 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ピロクトンオラミン: 本品は、次の化学式で表されるアミン塩である。

Source: JCIA labelling names (Japan)

Names & identifiers

PIROCTONE OLAMINEINCI피록톤올아민Korean label name (MFDS standard)2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)SynonymピロクトンオラミンJapanese labelling name

CAS No.chemical registry number: 68890-66-4
EC No.EU chemical inventory number: 272-574-2
DTXSIDUS EPA chemical ID: DTXSID4046735
DTXCIDUS EPA compound ID: DTXCID2026735

IUPAC: 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one--3-aminopropan-1-ol (1/1)
Molecular formula: C17H32N2O3
Molecular weight: 312.454 g/mol

Measured properties

Initial boiling point and range: &amp, lt, 344.1 °C at 760 mmHg ℃
Flash point: &amp, lt, 161.9 ℃
Molecular weight: 298.42

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative3
Biocide1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 3 eye studies are on record.

Classed as highly irritating1Classed as moderate6Classed as low2

The studies disagree (the most common conclusion covers 11%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Category 6.3B (Category 3)
Skin Irritation · Read Across
Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: FDA s1500.41 according to
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: FDA, Vol. 37, No. 38, 1972 according to
Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: FDA 38, No 187, 27.09.1973, p 27019 according to