Piroctone is a cyclic hydroxamic acid that consists of 1-hydroxypyridin-2-one bearing methyl and 2,4,4-trimethylpentyl substtituents at positions 4 and 6 respectively.
Definition
US FDA substance register · UNII R49EFA73Q7 · registered name PIROCTONE · single chemical substance
Piroctone is a cyclic hydroxamic acid that consists of 1-hydroxypyridin-2-one bearing methyl and 2,4,4-trimethylpentyl substtituents at positions 4 and 6 respectively. It has a role as an antiseborrheic. It is a cyclic hydroxamic acid, a pyridone and a hydroxypyridone antifungal drug.
Source: PubChem
Piroctone is the organic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
Restriction V/35
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 50650-76-5
- DTXSIDUS EPA chemical ID
- DTXSID2048298
- DTXCIDUS EPA compound ID
- DTXCID7028273
- IUPAC
- 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one
- Molecular formula
- C14H23NO2
- Molecular weight
- 237.343 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 108 ℃
- Initial boiling point and range
- 379.31 ℃
- Vapour pressure
- 1.14E-7 ㎜Hg (25℃)
- Water solubility
- 18.75 ㎎/ℓ (25℃)
- Vapour density
- 8.19261304798067
- Relative density
- 10.29
- n-Octanol/water partition coefficient (Kow)
- 3.71
- Molecular weight
- 237.34
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
Related literature
- Investigation of complexation behavior of piroctone olamine salt with Fe(III) ions and influence on antifungal activity · 2026
- Synergistic Antifungal Activity and Mechanism of Piroctone Olamine and Sorbitan Caprylate against Malassezia restricta. · 2026
- Characterization of piroctone olamine for topical delivery to the skin · 2023
- Investigation of piroctone olamine delivery to the skin from single, binary and ternary solvent systems · 2023
- Study of the effectiveness of shampoo application (combination of 3% salicylic acid, piroctone olamine and panthenol) as an external therapy of scalp psoriasis · 2023
Linked databases 12
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- KOSHA safety data sheets (Korea)
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata