Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group.
Definition
US FDA substance register · UNII 68IQX3T69U · registered name PROPAFENONE · single chemical substance
Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary alcohol, a secondary amino compound and an aromatic ketone. It is a conjugate base of a propafenone(1+).
Source: PubChem
Propafenone is the organic compound that conforms to the formula
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 54063-53-5
- DTXSIDUS EPA chemical ID
- DTXSID9045184
- DTXCIDUS EPA compound ID
- DTXCID7025184
- IUPAC
- 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
- Molecular formula
- C21H27NO3
- Molecular weight
- 341.451 g/mol
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinIrr2
Skin Irritation · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- (N-NITROSO) PROPAFENONE INDUCED ADVANCED NODULAR MELANOMA-FIRST REPORTED CASE IN THE WORLD LITERATURE: THE INEXTRICABLE LINKS BETWEEN THE PHOTOCARCINOGENESIS, DRUG RELATED NITROSOGENESIS AND PHARMACO-ONCOGENESIS. · 2024
- Neutropenia and cutaneous lesions secondary to propafenone. · 2009
- POLYPHARMACY, DRUG RELATED NITROSAMINE CONTAMINATION (BISOPROLOL/PROPAFENONE) AND THE LINK TO LICHEN PLANUS/SUBSEQUENT DEVELOPMENT OF KERATINOCYTE AND MUCOSAL CANCER/ORAL LEUKOPLAKIA: PRESENTATION OF THE FIRST CASE AND UPDATE ON THE NEW PATHOGENETIC VISION. · 2025
- MULTIPLE KERATINOCYTIC CANCERS AFTER INTAKE OF ANTIHYPERTENSIVES (LISINOPRIL/BISOPROLOL/HCT) AND ANTIARRHYTMICS (PROPAFENONE): THE IMPORTANT NEW LINKS TO THE NITROSO-CONTAMINATION AND THE METABOLIC REPROGRAMMING OF THE FUTURE CANCER CELL. · 2024
- Atrial fibrillation: focal or reentrant or both?: a new autonomic lens to examine an old riddle. · 2009
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
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