Definition
US FDA substance register · UNII K0MR13CZ2E · registered name PROPYLENE GLYCOL 1-BUTYL ETHER · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Amended Safety Assessment of Butyl Polyoxyalkylene Ethers as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ＰＧブチルエーテル: 本品は、ブタノール（＊）とプロピレングリコール（ＰＧ（＊））のエーテルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 29387-86-8
- CAS No.chemical registry number
- 5131-66-8
- CAS No.chemical registry number
- 15821-83-7
- EC No.EU chemical inventory number
- 249-598-7
- EC No.EU chemical inventory number
- 225-878-4
- DTXSIDUS EPA chemical ID
- DTXSID8027589
- DTXCIDUS EPA compound ID
- DTXCID707589
- IUPAC
- 1-Butoxypropan-2-ol
- Molecular formula
- C7H16O2
- Molecular weight
- 132.203 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Melting/freezing point
- -80 ℃
- Initial boiling point and range
- 171.5 ℃
- Flash point
- 54.5 ℃
- Evaporation rate
- 0.88
- Upper/lower flammability or explosive limits
- 8.4 / 1.1 %
- Vapour pressure
- 0.187 ㎪
- Water solubility
- 600000 ㎎/ℓ
- Vapour density
- 4.55
- Relative density
- 0.879 (at 25℃)
- n-Octanol/water partition coefficient (Kow)
- 0.98
- Auto-ignition temperature
- 260 ℃
- Viscosity
- 3.4 cP
- Molecular weight
- 132.2
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 153 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent95
- Solubility enhancer29
- Cleaning agent5
- Film former4
- Chemical reaction regulator4
- Surfactant (surface active agent)3
- Processing aids not otherwise specified2
- Fragrance2
7 other uses
- Pigment2
- Coalescing agent2
- Lubricating agent1
- Humectant1
- Corrosion inhibitor1
- Viscosity modifier1
- Intermediate1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
10 skin studies and 7 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 17 studies
- Skin corrosion/irritation - Category 2
Skin Irritation · Screening - Skin Irrit. 2
Skin Irritation · Authoritative - Not classified
Skin Sensitization · Screening - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Category 2
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to - Category 6.3A (Category 2)
Skin Irritation · Read Across - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Eye Irrit. 2
Eye Irritation · Authoritative - Category 2B
Eye Irritation · Screening - Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- Tlooto literature search
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Chinese