Propylparaben is the ester of n-propyl alcohol and p-hydroxybenzoic acid.
产品中实际含有多少
暂无产品标示该成分含量。
含该成分的产品中,13 款将其列在 1% 线之前,112 款列在之后(通常不超过 1%)。
含有此成分的产品
已确认 125 款中的 12 款 · 按含量充足程度排序 · 查看全部 125 款
NightingaleNightingale IPSE Collagen Foam Cleanser
ORLYORLY FUNGUS MD
TENZEROTENZERO Balancing Foam Cleanser Peptide Collagen
TENZEROTENZERO Balancing Foam Cleanser Hyaluronic Snail
TENZEROTENZERO Balancing Foam Cleanser Shea Butter Avocado
TENZEROTENZERO Balancing Foam Cleanser Strawberry
TENZEROTENZERO Balancing Foam Cleanser Apple
TENZEROTENZERO Balancing Foam Cleanser Rice
CIRACLEAqua Control Double Moisture Cream
LabottachVenolite 4 Patches
DASHUDASHU For Men Premium Ultra Holding Power Wax
MentholatumHandveil Beauty Premium Rich Nail Repair Coat 10ml
定义
Propylparaben is the ester of n-propyl alcohol and p-hydroxybenzoic acid. It conforms to the formula:
Propylparaben is the benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive. It has a role as an antimicrobial agent and an antifungal agent. It is a member of phenols, a benzoate ester and a paraben. It is functionally related to a propan-1-ol and a 4-hydroxybenzoic acid.
来源: PubChem
美国FDA 物质登记 · UNII Z8IX2SC1OH · 登记名称 Propylparaben · 单一化学物质
化妆品中的作用
安全与法规参考
- 限用
- 韩国 · 中国
来源: 韩国食药处 化妆品法规信息
阿根廷 · 巴西
- Maximum concentration permitted at final product : (a) 0,14% (expresso como ácido) para a soma das concentrações individuais. (b) 0,8% (expresso como ácido) para a soma das concentrações individuais das substâncias mencionadas nos itens 11 e 11-A contidos no produto; neste caso a soma das concentrações individuais de butil e propilparabeno e seus sais não devem superar 0,14% (expresso como ácido).
- Other limitations and requirements : Não usar em produtos que não se enxáguem destinados a área de fraldas em crianças menores de 3 anos.
- Use conditions and warnings that must appear on the label : Em produtos que não se enxáguem desenhados para crianças menores de 3 anos: "Não usar nas áreas das fraldas".
东盟
- Maximum authorised concentration in the finished cosmetic product : 0.4% (as acid) for single ester 0.8% (as acid) for mixtures of esters
台湾
- ※ 未列於本表中之防腐劑成分,倘歐、美、日三國家地區政府已公告准用且有其限量管制規定者,我國亦依其限用標準准予使用。
- 倘前述三國家地區政府管理有差異時,則採其中限量規定方式最安全者。
- ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
- 用途 : 防腐
- 最大配合量 : (a) 0.14% (以 acid 計) (總量)
- (b) 0.8 % (以acid計),混合使用編號32及33之成分,惟 butylparaben 和propylparaben 及其鹽類限量分別不得超過0.14 %
- 不得使用於三歲以下孩童使用於尿布部位之非立即沖洗之產品。
- (a) 0.14%
日本
- 每100g最大配合量(Maximum amount of ingredient per 100 g) : 1.0 as total(合計量として1.0)
欧盟
- Maximum concentration in ready for use preparation : - 0,14% (as acid) for the sum of the individual concentrations - 0,8% (as acid) for mixtures of substances mentioned in entry 12 and 12a, here the sum of the individual concentrations of butyl and propylparaben and their salts does not exceed 0,14%
- Other : Not to be used in leave-on products designed for application on the nappy area of children under three years of age.
- Wording of conditions of use and warnings : For leave-on products designed for children under three years of age: "Do not use on the nappy area"
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Restriction V/12 · SCCS opinion: Extended Opinion on the Safety Evaluation of Parabens; Opinion on Parabens; Opinion on Parabens updated request for a scientific opinion on 'propyl-and butylparaben'; Opinion on Parabens, underarm cosmetics and breast cancer; OPINION ON Propylparaben (PP)
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben and Benzylparaben as used in cosmetic products
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, and Butylparaben
来源: 美国CIR 安全性评估
Reviewed by CIR: Amended Safety Assessment of Parabens as Used in Cosmetics
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 プロピルパラベン: 本品は、パラヒドロキシ安息香酸とプロパノール(*)のエステルであり、次の化学式で表される。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 94-13-3
- EC No.欧盟化学品目录编号
- 202-307-7
- DTXSID美国EPA化学品编号
- DTXSID4022527
- DTXCID美国EPA化合物编号
- DTXCID602527
- IUPAC
- Propyl 4-hydroxybenzoate
- 分子式
- C10H12O3
- 分子量
- 180.203 g/mol
实测物性
- 性状
- Propyl-4-hydroxybenzoate appears as colorless crystals or white powder or chunky white solid. Melting point 95-98 °C. Odorless or faint aromatic odor. Low toxicity, Tasteless (numbs the tongue). pH: 6.5-7.0 (slightly acidic) in solution. · Liquid, Other Solid, Dry Powder
- 气味
- Odorless or has faint odor
- 沸点
- 271 °F at 1 mmHg (NTP, 1992) · 294.00 to 295.00 °C. @ 760.00 mm Hg
- 熔点
- 203 to 208 °F (NTP, 1992) · 96.1 °C
- 溶解性
- less than 1 mg/mL at 54 °F (NTP, 1992) · In water, 5.00X10+2 mg/L at 25 °C
- 密度
- 1.28 at 77 °F (NTP, 1992) - Denser than water, will sink · 1.287 g/cu cm at 20 °C
- 稳定性
- Stable under recommended storage conditions. · Parabens are stable against hydrolysis during autoclaving & resist saponification /Parabens/
- 颜色
- 白色
- 熔点/凝固点
- 97 ℃
- 初沸点和沸程
- 301 ℃(计算值)
- 闪点
- 180 ℃
- 易燃性(固体、气体)
- 易燃
- 蒸气压
- 0.000555 ㎜Hg (@ 25 ℃, 估算值)
- 溶解度
- 500 ㎎/ℓ (@ 25 ℃)
- 蒸气密度
- 6.22
- 比重
- 1.063 (@ 102 ℃)
- 正辛醇/水分配系数(Kow)
- 3.04
- 自燃温度
- 600 ℃
- 分子量
- 180.21
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 134 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Preservative119
- Fragrance9
- Processing aids not otherwise specified1
- Biocide1
- Flavouring and nutrient1
- Food preservative (EPA)1
- No specific technical function1
- Softener and conditioner1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 5 项、眼部试验 2 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 7 项试验
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.3B (Category 3)
Skin Irritation · Read Across - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) adopted in 1981 - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) adopted in 1987 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
来源: 美国EPA CompTox
相关文献
- Development and Validation of a Novel Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Halometasone, Fusidic Acid, Methylparaben, and Propylparaben in Topical Pharmaceutical Formulation · 2013
- Thermodynamic Analysis of the Solubility of Propylparaben in Acetonitrile–Water Cosolvent Mixtures · 2023
- Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design · 2023
- Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae · 2022
- Degradation of Tyrosinase by Melanosomal pH Change and a New Mechanism of Whitening with Propylparaben · 2017
关联数据库 23
- 澳大利亚工业化学品名录(AICIS)
- 韩国安全保健公团 安全数据表
- 韩国化妆品协会成分词典
- 韩国食药处 化妆品法规信息 2 3
- 韩国食药处 化妆品原料成分 2
- 韩国有毒物质 GHS 信息(环境公团)
- 美国CIR 安全性评估 2 3 4
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 欧盟 CosIng 成分清单 2
- 欧盟 SCCS 安全意见
- 日本化妆品工业联合会标示名称
- 中国已使用化妆品原料目录(IECIC)
- ChEBI
- ChEMBL
- NIST 化学网络手册
- PubChem 2
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata
- Wikipedia · 英语