What is this ingredient?

미국 FDA 물질 등록 · UNII A7V27PHC7A · 등록명 Quinine · 단일 화학물질

Ingredient Dictionary

QUININE

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.

Definition

US FDA substance register · UNII A7V27PHC7A · registered name Quinine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as a non-narcotic analgesic, an antimalarial and a muscle relaxant. It is a conjugate base of a quinine(1+). It derives from a hydride of an (8S)-cinchonan.

Source: PubChem

Quinine is an alkaloid from the bark of Cinchona officinalis. It conforms to the formula

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEMakes alcohol undrinkableDENATURANTSoftens hairHAIR CONDITIONING

Safety & regulatory references

Restricted: China · South Korea · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Argentina · Brazil

Field of application and/or use : Shampoos (a) (b) Hair lotions
Maximum concentration permitted at final product : a) 0.5 % calculated as quinine b) 0.2 % calculated as quinine

ASEAN

Field of application and/or use : (a) Shampoos (b) Hair lotions
Maximum authorised concentration in the finished cosmetic product : (a) 0.5% calculated as quinine base (b) 0.2% calculated as quinine base

European Union

Product Type, body parts : (a) Hair rinse-off products (b) Hair leave-on products
Maximum concentration in ready for use preparation : (a) 0.5% (as quinine base) (b) 0.2% (as quinine base)

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 21 · maximum concentration (a) 0.5% (as quinine base) (b) 0.2% (as quinine base) · applies to (a) Hair rinse-off products (b) Hair leave-on products

Source: EU restricted substances (Annex III)

Restriction III/21 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

QUININEINCI퀴닌Korean label name (MFDS standard)Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-SynonymCINCHONAN-9-OL, 6'-METHOXY-, (8.ALPHA.,9R)- ITS SALTSSynonym

CAS No.chemical registry number: 130-95-0
EC No.EU chemical inventory number: 205-003-2
DTXSIDUS EPA chemical ID: DTXSID0044280
DTXCIDUS EPA compound ID: DTXCID60819897

IUPAC: (9R)-6'-Methoxy-3alpha,8alpha-cinchonan-9-ol
Molecular formula: C20H24N2O2
Molecular weight: 324.424 g/mol

Measured properties

Appearance: Solid · Triboluminescent, orthorhombic needles from absolute alcohol
Odour: ODORLESS · odourless
Melting point: 57 °C · 177 °C (some decomposition)
Solubility: 500 mg/L (at 15 °C) · In water, 500 mg/L at 15 °C
Stability: Quinine sulfate darkens on exposure to light. Quinine sulfate capsules should be stored in tight, light-resistant containers at a temperature less than 40 °C, preferably between 15-30 °C. Quinine sulfate tablets should be stored in well-closed containers at a temperature less than 40 °C, preferably between 15-30 °C. /Quinine sulfate/ · Stable under recommended storage conditions.
pH: pH of saturated aqueous solution = 8.8 · (8.8)
Dissociation constant: 8.56 · 8.55
Melting/freezing point: (173-177 C)
Molecular weight: 324.41

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)1
Deodorizer1
Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 0 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
SkinIrr2
Skin Irritation · QSAR Predicted