Raspberry ketone is a ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group.
How much products actually contain
No product states its amount yet.
Of the products containing it, 14 list it before the 1% line and 126 after it (usually 1% or less).
Products using this ingredient
12 of 140 confirmed · likeliest to carry enough first · See all 140
ScinicScinic Hyaluronic Acid Ampoule Toner
IGK HairIGK Hair Color Depositing Gloss Mask - Arctic Halo
IGK HairIGK Hair Color Depositing Gloss Mask - Burning Love
IGK HairIGK Hair Color Depositing Gloss Mask - Tuscan Glow
ScinicScinic Hyaluronic Acid Cream
ScinicScinic Hyaluronic Acid Lotion
NaturiumNaturium UV Reflect Antioxidant SPF 50
DermalogicaDermalogica liquid peelfoliant
Live TintedLive Tinted HUESKIN Hydrating Serum Concealer
DermalogicaDermalogica powerbright dark spot serum
RotheaResilience Cream
ESFOLIOEsfolio Hyaluronic Acid Houttuynia Cordata Cleansing Foam 100ml
Definition
Raspberry ketone is a ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics. It has a role as a metabolite, an androgen antagonist, a flavouring agent, a fragrance, a hepatoprotective agent and a cosmetic. It is a member of phenols and a methyl ketone.
Source: PubChem
US FDA substance register · UNII 7QY1MH15BG · registered name 4-(P-HYDROXYPHENYL)-2-BUTANONE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- International fragrance standard (IFRA)
Source: IFRA fragrance standards
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ラズベリーケトン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 5471-51-2
- EC No.EU chemical inventory number
- 226-806-4
- DTXSIDUS EPA chemical ID
- DTXSID5044495
- DTXCIDUS EPA compound ID
- DTXCID3024495
- IUPAC
- 4-(4-Hydroxyphenyl)butan-2-one
- Molecular formula
- C10H12O2
- Molecular weight
- 164.204 g/mol
Measured properties
- Appearance
- solid · Dry Powder, CBI, Liquid
- Colour
- white
- Melting/freezing point
- 82.5 ℃
- Initial boiling point and range
- 83~84 ℃
- Flash point
- 123 ℃
- Vapour pressure
- 0.001 ㎜Hg(at 25℃)
- Vapour density
- 5.66
- n-Octanol/water partition coefficient (Kow)
- 0.94
- Molecular weight
- 164.22
- Odour
- Sweet fruity, warm odor resembling raspberry preserve
- Boiling point
- Decomposes · 200.00 °C. @ 760.00 mm Hg
- Melting point
- 82.5 °C
- Solubility
- 1 g in 1 mL 98% alcohol · Soluble in oils, moderately soluble in ethanol
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea) · PubChem
What products actually use it for
What the 168 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance157
- Deodorizer4
- Softener and conditioner3
- Flavouring and nutrient3
- Processing aids not otherwise specified1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- In Vitro Safety Profiling and Leukoderma-Relevant Hazard Assessment of Raspberry Ketone Versus Polygonum cillinerve Total Anthraquinones in a Keratinocyte–Melanocyte Co-Culture Model · 2026
- An ADH toolbox for raspberry ketone production from natural resources via a biocatalytic cascade · 2021
- Detection of Raspberry Ketone after Percutaneous Absorption of Rhododendrol-Containing Cosmetics and Its Mechanism of Formation · 2021
- Acute feeding suppression and toxicity of raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] in mice. · 2020
- Tyrosinase-Catalyzed Oxidation of the Leukoderma-Inducing Agent Raspberry Ketone Produces (E)-4-(3-Oxo-1-butenyl)-1,2-benzoquinone: Implications for Melanocyte Toxicity. · 2017
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese