All-trans Retinoic Acid can cause developmental toxicity according to an independent committee of scientific and health experts.
Definition
All-trans Retinoic Acid can cause developmental toxicity according to an independent committee of scientific and health experts.
Source: PubChem
US FDA substance register · UNII 5688UTC01R · registered name Tretinoin · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 375
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/375 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name トレチノイン: 本品は、ビタミンＡ酸である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 302-79-4
- EC No.EU chemical inventory number
- 206-129-0
- DTXSIDUS EPA chemical ID
- DTXSID7021239
- DTXCIDUS EPA compound ID
- DTXCID001239
- IUPAC
- Retinoic acid
- Molecular formula
- C20H28O2
- Molecular weight
- 300.442 g/mol
Measured properties
- Melting/freezing point
- 180~182 ℃
- Vapour pressure
- 1.02E-7 ㎜Hg (25℃)
- Water solubility
- 0.0248 ㎎/ℓ (25℃)
- Vapour density
- 10.37
- n-Octanol/water partition coefficient (Kow)
- 6.3
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- No specific technical function1
Source: US EPA CompTox dashboard
Related literature
- Expression of retinoic acid-binding proteins and retinoic acid receptors in sebaceous cell carcinoma of the eyelids · 2015
- Retinoic acid and cancer treatment · 2014
- Liarozole inhibits human epidermal retinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo. · 1996
- Retinoic acid in acne therapy. · 1976
- A retinoic acid-binding protein from chick embryo skin. · 1976
Linked databases 22
- ASEAN Cosmetic Directive
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese