Riboflavin is D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety.
How much products actually contain
50 products state the amountmedian 0.000001%
- under 0.01% 50
- 0.01–0.1% 0
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 32 list it before the 1% line and 215 after it (usually 1% or less).
Products using this ingredient
12 of 246 confirmed · likeliest to carry enough first · See all 246
BanobagiVita Genic Jelly Mask (10 Sheets), 7 Types0.00001% stated
MIPVita Energy Cleansing Foam0.00001% stated
REPLYMEZanmang Loopy Biocellulose Vitamin Facial Fit Mask Pack0.000004% stated
MEDIPEELMEDIPEEL Vegan Vitamin Deep-Tox Cleansing Oil0.00000001% stated
MEDIPEELMEDIPEEL [Makeup Deep Cleansing] Vegan Vitamin Deep-Tox Cleansing Oil 200ml0.00000001% stated
MEDIPEELMEDIPEEL Algo-Tox Vita Cleanser 150ml0% stated
PUREDERMGold Energy Hydrogel Eye Patch
REPLYMEZanmang Loopy TPO Interview Pack Radiance
RahuaRahua Enchanted Island™ Conditioner
RahuaRahua Enchanted Island™ Conditioner Refill
RahuaRahua Enchanted Island™ Shampoo
AROMATICARosemary Root Enhancer 100ml
Definition
US FDA substance register · UNII TLM2976OFR · registered name Riboflavin · single chemical substance
Riboflavin is D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. It has a role as an antioxidant, a cofactor, a photosensitizing agent, an anti-inflammatory agent, a mouse metabolite, a plant metabolite, an Escherichia coli metabolite, a food colouring, a fundamental metabolite and a human urinary metabolite. It is a vitamin B2 and a flavin. It is a conjugate acid of a riboflavin(1-).
Source: PubChem
Riboflavin is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted
- ASEAN · China · South Korea · Taiwan
- Allowed colourant
- ASEAN · Taiwan · United Kingdom · United States
Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS) · US FDA color additives · US FDA prohibited and restricted ingredients
Argentina · Brazil
- Field of application and/or use : Dye Substances allowed for all kinds of products.
European Union
- Other : Purity criteria as set out in Commission Directive 95/45/EC (E101)
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex IV (allowed colourants), entry 145
Source: EU allowed colourants (Annex IV)
Restriction IV/145
Source: EU CosIng ingredient list
Restriction IV/145 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name リボフラビン: 本品は、ビタミンB2であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 83-88-5
- EC No.EU chemical inventory number
- 201-507-1
- DTXSIDUS EPA chemical ID
- DTXSID8021777
- DTXCIDUS EPA compound ID
- DTXCID401777
- IUPAC
- 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-D-ribitol
- Molecular formula
- C17H20N4O6
- Molecular weight
- 376.369 g/mol
Measured properties
- Appearance
- Yellow to orange-yellow crystalline powder, with slight odour · Orange-yellow solid, [Merck Index] Dark yellow powder, [Sigma-Aldrich MSDS]
- Odour
- Slight odor
- Melting point
- 280 dec °C · 280 °C (decomposes)
- Solubility
- 84.7 mg/L (at 25 °C) · Soluble in sodium chloride solutions, 0.0045 g/100 mL of absolute ethanol at 27.5 °C, slightly sol in cyclohexanol, amyl acetate and benzyl alcohol, phenol, insoluble in ether, chloroform, acetone, benzene, very soluble in dilute alkalies (with decomposition)
- Stability
- Crystalline riboflavin shows no evidence of decomposition under ordinary conditions, but protection from light is advisable · Solutions undergo decomp under the influence of visible or ultraviolet light
- pH
- pH of saturated aqueous solution: about 6 · 6
- Dissociation constant
- 10.2 · pKa = 10.2, pKb = 1.7
- Melting/freezing point
- 280 ℃
- Vapour pressure
- 8.92E-22 ㎜Hg
- n-Octanol/water partition coefficient (Kow)
- -1.46
- Decomposition temperature
- 280 ℃
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 21 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye9
- Flavouring and nutrient7
- Pharmaceutical (EPA)3
- Softener and conditioner2
Source: US EPA CompTox dashboard
Related literature
- Riboflavin and health: A review of recent human research · 2017
- Maternal riboflavin deficiency · 2020
- Riboflavin for women’s health and emerging microbiome strategies · 2024
- Microbial production of riboflavin: Biotechnological advances and perspectives. · 2021
- Corneal riboflavin gradients and UV-absorption characteristics after topical application of riboflavin in concentrations ranging from 0.1 to 0.5. · 2021
Linked databases 28
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed colourants (Annex IV)
- EU CosIng ingredient list 2 3
- EU Cosmetics Regulation
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA color additives
- US FDA prohibited and restricted ingredients
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese