Salicylaldehyde is a hydroxybenzaldehyde carrying a hydroxy substituent at position 2.
Definition
Salicylaldehyde is a hydroxybenzaldehyde carrying a hydroxy substituent at position 2. It has a role as a nematicide and a plant metabolite.
Source: PubChem
US FDA substance register · UNII 17K64GZH20 · registered name Salicylaldehyde · single chemical substance
Salicylaldehyde is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
European Union
- Other : The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 340
Restriction III/340
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name サリチルアルデヒド: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 90-02-8
- EC No.EU chemical inventory number
- 201-961-0
- DTXSIDUS EPA chemical ID
- DTXSID1021792
- DTXCIDUS EPA compound ID
- DTXCID001792
- IUPAC
- 2-Hydroxybenzaldehyde
- Molecular formula
- C7H6O2
- Molecular weight
- 122.123 g/mol
Measured properties
- Appearance
- Liquid, colorless or pale yellow, bitter almond odor. Sinks and mixes slowly in water. (USCG, 1999) · Liquid
- Odour
- Bitter, almond-like odor · Pungent, irritating odor similar to benzenaldehyde, acetophenone, and nitrobenzene, but with phenolic notes
- Boiling point
- 386 °F at 760 mmHg (USCG, 1999) · 197 °C
- Melting point
- 19.4 °F (USCG, 1999) · -7 °C
- Solubility
- Solubility in water, 1.7X10+4 mg/L at 86 °C · Slightly soluble in water
- Density
- 1.1674 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.167 g/cu cm at 20 °C/4 °C
- Stability
- Stable under recommended storage conditions.
- Viscosity
- Dynamic viscosity = 2.50X10-3 Pa.s at 25 °C
- Melting/freezing point
- -7 ℃
- Initial boiling point and range
- 197 ℃
- Flash point
- 78 ℃(C.C.)
- Vapour pressure
- 0.593 ㎜Hg (25℃)
- Water solubility
- 1.7 g/100㎖ (86℃)
- Vapour density
- 4.2
- Relative density
- 1.167 (20℃)
- n-Octanol/water partition coefficient (Kow)
- 1.81
- Molecular weight
- 122.12
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance3
- Flavouring and nutrient2
- No specific technical function1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- Classification not possible
Skin Sensitization · Screening - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Category 6.3A (Category 2)
Skin Irritation · Read Across - Not classified
Skin Irritation · Screening - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Salicylaldehyde Suppresses IgE-Mediated Activation of Mast Cells and Ameliorates Anaphylaxis in Mice · 2022
- Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling · 2025
- Sensitive Detection of Sulfur Mustard Poisoning via N-Salicylaldehyde Naphthyl Thiourea Probe and Investigation into Detoxification Scavengers. · 2024
- Multicomponent Synthesis of Trifluoromethyl-1H-benzo[f]chromenes Using Kit-6-NH2@Schiff Base Complex Nanoparticles · 2023
- Synthesis, Biological Activity and Molecular Docking Studies of Novel Sulfonate Derivatives Bearing Salicylaldehyde · 2022
Linked databases 22
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese