Ingredient Dictionary

SALICYLAMIDE

Salicylamide is the simplest member of the class of salicylamides derived from salicylic acid.

Definition

Salicylamide is the simplest member of the class of salicylamides derived from salicylic acid. It has a role as a non-narcotic analgesic and an antirheumatic drug. It is a member of phenols and a member of salicylamides.

Source: PubChem

US FDA substance register · UNII EM8BM710ZC · registered name Salicylamide · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Softens and loosens the outer layerKERATOLYTIC

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

SALICYLAMIDEINCI살리실아마이드Korean label name (MFDS standard)Benzamide, 2-hydroxy-Synonym

CAS No.chemical registry number: 65-45-2
EC No.EU chemical inventory number: 200-609-3
DTXSIDUS EPA chemical ID: DTXSID3021726
DTXCIDUS EPA compound ID: DTXCID501726

IUPAC: 2-Hydroxybenzamide
Molecular formula: C7H7NO2
Molecular weight: 137.138 g/mol

Measured properties

Appearance: 2-hydroxybenzamide appears as odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82 °F) about 5. Sublimation begins at the melting point. (NTP, 1992) · Solid
Boiling point: 518 °F at 760 mmHg (decomposes) (NTP, 1992) · 181.5 °C
Melting point: 284 °F (NTP, 1992) · 142 °C
Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) · 2060 mg/L (at 25 °C)
Density: 1.175 at 284 °F (NTP, 1992) - Denser than water, will sink · 1.175 @ 140 °C/4 °C
Stability: DEVELOPS SLIGHT PINK COLOR ON EXPOSURE TO LIGHT, THEREFORE STORE IN LIGHT RESISTANT CONTAINERS · STABLE IN AIR
pH: ABOUT 5 @ 28 °C (AQ SOLN) · 4~5
Dissociation constant: 8.37 (at 20 °C) · pKa = 8.37 20 °C
Odour: odourless
Melting/freezing point: 138.7 ℃
Initial boiling point and range: 181.5 ℃(1.9 kPa)
Vapour pressure: 0.00097 ㎩ (20 °C)
Water solubility: 1980 ㎎/ℓ (20 °C)
Relative density: 1.175 (140 °C)
n-Octanol/water partition coefficient (Kow): 1.28
Molecular weight: 137.1373

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: B46 of Council Regulation (EC) No 761/2009 according to
Classification not possible
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Classification not possible
Eye Irritation · Screening
Moderate or Mild Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD 437 (adopted 7 September 2009) according to