Salicylamide is the simplest member of the class of salicylamides derived from salicylic acid.
定义
Salicylamide is the simplest member of the class of salicylamides derived from salicylic acid. It has a role as a non-narcotic analgesic and an antirheumatic drug. It is a member of phenols and a member of salicylamides.
来源: PubChem
美国FDA 物质登记 · UNII EM8BM710ZC · 登记名称 Salicylamide · 单一化学物质
化妆品中的作用
软化并松解角质层KERATOLYTIC
安全与法规参考
未列入韩国有毒物质 GHS 分类
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
SALICYLAMIDEINCI살리실아마이드韩国标示名称（食药处标准名）Benzamide, 2-hydroxy-同义名
- CAS No.化学物质登记号
- 65-45-2
- EC No.欧盟化学品目录编号
- 200-609-3
- DTXSID美国EPA化学品编号
- DTXSID3021726
- DTXCID美国EPA化合物编号
- DTXCID501726
- IUPAC
- 2-Hydroxybenzamide
- 分子式
- C7H7NO2
- 分子量
- 137.138 g/mol
实测物性
- 性状
- 2-hydroxybenzamide appears as odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82 °F) about 5. Sublimation begins at the melting point. (NTP, 1992) · Solid
- 沸点
- 518 °F at 760 mmHg (decomposes) (NTP, 1992) · 181.5 °C
- 熔点
- 284 °F (NTP, 1992) · 142 °C
- 溶解性
- less than 1 mg/mL at 68 °F (NTP, 1992) · 2060 mg/L (at 25 °C)
- 密度
- 1.175 at 284 °F (NTP, 1992) - Denser than water, will sink · 1.175 @ 140 °C/4 °C
- 稳定性
- DEVELOPS SLIGHT PINK COLOR ON EXPOSURE TO LIGHT, THEREFORE STORE IN LIGHT RESISTANT CONTAINERS · STABLE IN AIR
- pH
- ABOUT 5 @ 28 °C (AQ SOLN) · 4~5
- 解离常数
- 8.37 (at 20 °C) · pKa = 8.37 20 °C
- 气味
- 无臭
- 熔点/凝固点
- 138.7 ℃
- 初沸点和沸程
- 181.5 ℃(1.9 kPa)
- 蒸气压
- 0.00097 ㎩ (20 °C)
- 溶解度
- 1980 ㎎/ℓ (20 °C)
- 比重
- 1.175 (140 °C)
- 正辛醇/水分配系数（Kow）
- 1.28
- 分子量
- 137.1373
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 4 项、眼部试验 2 项。
归类为低2 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 6 项试验
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: B46 of Council Regulation (EC) No 761/2009 according to - Classification not possible
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Classification not possible
Eye Irritation · Screening - Moderate or Mild Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD 437 (adopted 7 September 2009) according to
来源: 美国EPA CompTox
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- Solubility and Partition Coefficient of Salicylamide in Various pH Buffer Solutions · 2021
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