Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position.
- Blemishes B
- Dark spots B-
- Pores C
- Oiliness D
- Amount studies used
- 0.5–2%
- When
- evening
- Irritation
- moderate — start every other day
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
63 products state the amountmedian 0.5%54% at or above the amount studies used (0.5–2%)
- under 0.01% 7
- 0.01–0.1% 13
- 0.1–1% 35
- 1% or more 8
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 571 list it before the 1% line and 497 after it (usually 1% or less).
Where no amount is stated, a product listing it early reaches the study amount about 59% of the time, one listing it late about 9%.
Clinical evidence grade by skin concern
- B
- one or two randomised trials
- C
- uncontrolled or multi-ingredient studies
- D
- lab work or a record only
Do not use it if you are allergic to aspirin.
Products using this ingredient
12 of 1,063 confirmed · likeliest to carry enough first · See all 1,063
MuradMurad Rapid Relief Acne Spot Treatment2% stated · study amount
MuradMurad Retexturizing Body Pads2% stated · study amount
First Aid BeautyFirst Aid Beauty Body Acne Clearing Mist with 2% Salicylic Acid2% stated · study amount
NaturiumNaturium Salicylic Acid Serum 2%2% stated · study amount
Peach & LilyPeach & Lily Acne Clarifying Cleanser2% stated · study amount
Peach & LilyPeach & Lily Acne Exfoliating Toner2% stated · study amount
COSRXCOSRX The AHA BHA PHA LHA 35 Peel2% stated · study amount
TOSOWOONGSalicylic Acid Foam Cleansing1.8% stated · study amount
MuradMurad Clarifying Body Spray0.5% stated · study amount
MuradMurad Clarifying Cream Cleanser0.5% stated · study amount
Peach & LilyPeach & Lily Acne Oil-Free Moisturizer0.5% stated · study amount
DermalogicaDermalogica acne biotic moisturizer0.5% stated · study amount
Definition
Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. It has a role as an antiinfective agent, an antifungal agent, a plant hormone, a keratolytic drug, an EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor, a plant metabolite and an algal metabolite. It is a conjugate acid of a salicylate.
Source: PubChem
US FDA substance register · UNII O414PZ4LPZ · registered name Salicylic Acid · single chemical substance
Salicylic Acid is the aromatic acid that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted
- South Korea · United Kingdom
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS) · Japan Standards for Cosmetics
Argentina · Brazil
- Field of application and/or use : (a) hair products that are rinsed (b) Other products
- Maximum concentration permitted at final product : (a) 3% (b) 2%
- Other limitations and requirements : Should not be used in products in products for children under 3 years old, except for shampoos.
- Use conditions and warnings that must appear on the label : -For adult use products: "Do not use in children” - For products designed for children public: "Do not use in children under 3 years old".
- Maximum concentration permitted at final product : 0.5% (expressed as acid)
- Other limitations and requirements : Prohibited in products for children under 3 years of age, except for shampoos.
- Use conditions and warnings that must appear on the label : Products for use Adults: "Do not use in children" For products aimed at children: "Do not use in children under three years of age (except shampoo)"
ASEAN
- Field of application and/or use : (a) Rinse-off hair products (b) Other products except body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant (c) Body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant
- Maximum authorised concentration in the finished cosmetic product : (a) 3.0 % (b) 2.0% (c) 0.5%
- Other limitations and requirements : (a) (b) (c) Not to be used in preparations for children under 3 years of age. Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Not to be used in oral products. For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product. These levels are inclusive of any use of salicylic acid. As a preservative, see Annex VI, Part 1, No 3
- Conditions of use and warning which must be printed on the labels : (a) (b) (c) Not to be used for children under three years of age
- Solely for products which might be used for children
- Maximum authorised concentration in the finished cosmetic product : Salicylic acid: 0,5 % (acid) Salicylic acid salts: 0,5 % (acid)
- Other limitations and requirements : Salicylic acid: Not to be used in products for children under 3 years of age. Not to be used in oral products. Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Salicylic acid salts: Not to be used in products for children under 3 years of age, except for shampoos.
- Conditions of use and warning which must be printed on the labels : Salicylic acid: Not to be used for children under 3 years of age Salicylic acid salts: Not to be used for children under 3 years of age
Canada
- Maximum Concentration Permitted : 2%
Taiwan
- Maximum concentration : 2%
Japan
- Maximum amount per 100 g(Maximum amount of ingredient per 100 g) : 0.20(0.20 g)
China
- Maximum concentration : (a) 2.0%
- (b) 3.0%
European Union
- Product Type, body parts : (a) Rinse-off hair products (b) Other products except body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant (c) Body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant
- Maximum concentration in ready for use preparation : (a) 3.0% (b) 2.0% (c) 0.5%
- Other : (a) (b) (c) Not to be used in preparations for children under 3 years of age. Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Not to be used in oral products. For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product. These levels are inclusive of any use of salicylic acid.
- Wording of conditions of use and warnings : (a) (b) (c) Not to be used for children under three years of age
- Solely for products which might be used for children under 3 years of age.
- Maximum concentration in ready for use preparation : Salicylic acid: 0,5 % (acid) Salicylic acid salts: 0,5 % (acid)
- Other : Salicylic acid: Not to be used in products for children under 3 years of age. Not to be used in oral products. Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Salicylic acid salts: Not to be used in products for children under 3 years of age, except for shampoos.
- Wording of conditions of use and warnings : Salicylic acid: Not to be used for children under 3 years of age **Solely for products which might be used for children under 3 years of age. Salicylic acid salts: Not to be used for children under 3 years of age ***Solely for products which might be used for children under 3 years of age and which remain in prolonged contact with the skin.
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 98 · maximum concentration (a) 3.0% (b) 2.0% (c) 0.5% · applies to (a) Rinse-off hair products (b) Other products except body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant (c) Body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant
Restriction III/98 V/3 · SCCS opinion: OPINION ON salicylic acid (CAS 69-72-7) Submission I
Source: EU CosIng ingredient list
Reviewed by CIR: Amended Safety Assessment of Salicylic Acid and Salicylates as Used in Cosmetics
Reviewed by CIR: Final Report on the Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name サリチル酸: 本品は、次の化学式で表される芳香族カルボン酸である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 69-72-7
- EC No.EU chemical inventory number
- 200-712-3
- DTXSIDUS EPA chemical ID
- DTXSID7026368
- DTXCIDUS EPA compound ID
- DTXCID206368
- IUPAC
- 2-Hydroxybenzoic acid
- Molecular formula
- C7H6O3
- Molecular weight
- 138.122 g/mol
Measured properties
- Appearance
- Salicylic acid is an odorless white to light tan solid. Sinks and mixes slowly with water. (USCG, 1999) · Wet Solid, Other Solid, Dry Powder, Liquid
- Odour
- SYNTHETIC ACID IS ODORLESS · odourless
- Boiling point
- 211 °C at 2.00E+01 mm Hg · 211 °C at 20 torr
- Melting point
- 315 °F (USCG, 1999) · 158 °C
- Solubility
- 2240 mg/L (at 25 °C) · Solubility (weight percent): carbon tetrachloride 0.262 (25 °C), benzene 0.775 (25 °C), propanol 27.36 (21 °C), absolute ethanol 34.87 (21 °C), acetone 396 (23 °C)
- Density
- 1.44 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.443 g/cu cm at 20 °C/4 °C
- Stability
- GRADUALLY DISCOLORS IN SUNLIGHT
- pH
- pH of saturated solution: 2.4 · 2.4
- Dissociation constant
- 2.78 · 2.88
- Colour
- colourless
- Melting/freezing point
- 159 ℃
- Initial boiling point and range
- 211 ℃(at 20 torr)
- Flash point
- 157 ℃(c.c.)
- Flammability (solid, gas)
- combustible
- Upper/lower flammability or explosive limits
- - / 1.1 % (at 200 ℃)
- Vapour pressure
- 0.000082 ㎜Hg (at 25 ℃)
- Water solubility
- 2240 ㎎/ℓ (at 25 ℃)
- Vapour density
- 4.8
- Relative density
- 1.443 (at 20 ℃)
- n-Octanol/water partition coefficient (Kow)
- 2.26
- Auto-ignition temperature
- 540 ℃
- Molecular weight
- 138.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 80 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Pharmaceutical (EPA)39
- Preservative7
- Softener and conditioner6
- Processing aids not otherwise specified5
- Flavouring and nutrient4
- Anti-dandruff (EPA)3
- Solvent3
- Intermediate2
8 other uses
- Propellants, non-motive (blowing agents)2
- Fragrance2
- Deodorizer2
- Chemical reaction regulator1
- Elasticizer1
- Abrasive1
- Monomers1
- Hardener1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 3 eye studies are on record.
The studies disagree (the most common conclusion covers 20%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Category 2
Skin Irritation · Screening - Category 1
Skin Sensitization · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2A
Eye Irritation · Screening - Eye damage - category 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
Linked databases 31
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions 2 3 4
- Health Canada Cosmetic Ingredient Hotlist
- Japan Standards for Cosmetics
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients 2
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS) 2
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese