Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups.
Definition
Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as an antihypertensive agent, an antilipemic drug, an immunosuppressive agent, an anti-allergic agent, an anti-inflammatory agent and a plant metabolite. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.
Source: PubChem
US FDA substance register · UNII H5841PDT4Y · registered name SCOPARONE · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 120-08-1
- EC No.EU chemical inventory number
- 204-369-0
- DTXSIDUS EPA chemical ID
- DTXSID10152640
- DTXCIDUS EPA compound ID
- DTXCID7075131
- IUPAC
- 6,7-Dimethoxy-2H-1-benzopyran-2-one
- Molecular formula
- C11H10O4
- Molecular weight
- 206.197 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Recent advances in bioactive coumarin scoparone: A comprehensive review. · 2025
- Fraxetin Interacts Additively with Cisplatin and Mitoxantrone, Antagonistically with Docetaxel in Various Human Melanoma Cell Lines—An Isobolographic Analysis · 2022
- Novel pentapeptide activators of mammalian and mushroom tyrosinase. · 2014
- Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone · 2012
- Stimulating effect of kaempferol and six traditional Chinese medicines on activation of tyrosinase · 2006
Linked databases 13
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese