Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
How much products actually contain
No product states its amount yet.
Of the products containing it, 2 list it before the 1% line and 4 after it (usually 1% or less).
Products using this ingredient
6 of 6 confirmed · likeliest to carry enough first
MEDIPEELMEDIPEEL Retinol Collagen Lifting Toner 150ml
MEDIPEELMEDIPEEL Retinol Collagen Lifting Ampoule 50ml
MEDIPEELMEDIPEEL Retinal Collagen Lifting Cream 50ml
MEDIPEELRetinal NMN Bounce Shot Eye Cream
MEDIPEELMEDIPEEL Retinal NMN Bounce Shot Booster 30ml
MEDIPEELMEDIPEEL Retinal NMN Bounce Shot Eye Cream 15ml
Definition
US FDA substance register · UNII 33X338MNE4 · registered name SILIBININ A · single chemical substance
Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a secondary alpha-hydroxy ketone, a polyphenol, an aromatic ether, a benzodioxine and a flavonolignan.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name シリビン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 22888-70-6
- EC No.EU chemical inventory number
- 245-302-5
- DTXSIDUS EPA chemical ID
- DTXSID8026018
- DTXCIDUS EPA compound ID
- DTXCID106018
- IUPAC
- (2R,3R)-3,5,7-Trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-1-benzopyran-4-one
- Molecular formula
- C25H22O10
- Molecular weight
- 482.441 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Silybin-Collagen XVII Composite Nanoemulsion for Enhanced Solubility, Skin Permeation, and Repair of UVB-Induced Skin Photodamage. · 2026
- New modified silybin derivatives: design, synthesis, and preliminary evaluation of antitumor activity · 2025
- Anti-Aging Efficacy of a Multi-Peptides–Silybin Complex: Mechanistic Insights and a 56-Day Clinical Evaluation · 2025
- Insight into the inhibitory activity of mangiferin and Silybin against HER2 and EGFR using theoretical and experimental approaches · 2025
- An Innovative Serum With Retinol, Hydroxypinacolone Retinoate, Peptides, and Silybin Improves Mild Photoaged Facial Skin in Middle‐Aged Chinese Women · 2025
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese