What is this ingredient?

미국 FDA 물질 등록 · UNII DIG6BWZ9XT · 등록명 SODIUM HYDROXYMETHYLGLYCINATE · 단일 화학물질

All ingredients

Ingredient Dictionary

SODIUM HYDROXYMETHYLGLYCINATE

Korean limit: 0.5%

How much products actually contain

No product states its amount yet.

Of the products containing it, 2 list it before the 1% line and 2 after it (usually 1% or less).

Products using this ingredient

4 of 4 confirmed · likeliest to carry enough first

Definition

US FDA substance register · UNII DIG6BWZ9XT · registered name SODIUM HYDROXYMETHYLGLYCINATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Sodium Hydroxymethylglycinate is the sodium salt of the substituted amino acid that conforms to the formula:

Cosmetic roles

Softens hairHAIR CONDITIONINGStops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Banned: European Union
Restricted or banned: European Union
Allowed preservative: European Union · United Kingdom

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.5%

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.5%
Other limitations and requirements : Not to be used if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, if the mixture as placed on the market is ≥ 0,1 % w/w

Taiwan

Maximum concentration : 0.5%
0.5%

China · South Korea

Maximum concentration : 0.5%

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 51 · maximum concentration 0.5%

Source: EU allowed preservatives (Annex V)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1669

Source: EU prohibited substances (Annex II)

Restriction V/51 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヒドロキシメチルグリシンＮａ: 本品は、アミノ酸誘導体のナトリウム塩であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

SODIUM HYDROXYMETHYLGLYCINATEINCI소듐하이드록시메칠글리시네이트Korean label name (MFDS standard)Glycine, N-(hydroxymethyl)-, monosodium saltSynonymヒドロキシメチルグリシンＮａJapanese labelling name

CAS No.chemical registry number: 70161-44-3
EC No.EU chemical inventory number: 274-357-8
DTXSIDUS EPA chemical ID: DTXSID5035799
DTXCIDUS EPA compound ID: DTXCID3015799

IUPAC: Sodium N-(hydroxymethyl)glycinate
Molecular formula: C3H6NNaO3
Molecular weight: 127.075 g/mol

Measured properties

Appearance: Other Solid

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 35 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative33
Biocide1
Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as moderate5Classed as low2

The study conclusions largely agree (71%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Ambiguous
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation)
Moderate or Mild Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation)
Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: The modified methods employed are described in the Hazardous Substances Labeling Act Regulations, Code of Federal Regulations 16, Part 1500.41. according to
Moderate or Mild Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across