What is this ingredient?

미국 FDA 물질 등록 · UNII 1V74VH163T · 등록명 SODIUM PIDOLATE · 단일 화학물질

Are there usage precautions?

강력한 수분 보유(표피에 보습막 형성), 각질층 천연보습인자(NMF), 피부탄력·윤기 부여, 자극 최소화 Sodium PCA is a naturally occurring component of the skin's natural moisturizing factor (NMF), derived from the amino acid proline. It binds water molecules from the environment and deeper skin layers, creating a reservoir of moisture in the skin’s outer layer (stratum corneum). This helps reduce transepidermal water loss (TEWL), keeps the skin plump, smooth, and elastic, and supports the skin barrier function. Sodium PCA also exhibits anti-inflammatory properties and helps reduce skin irritation. Regular use improves skin texture, resilience, and may relieve conditions like eczema. (추천 피부타입: 모든피부타입)

All ingredients

Ingredient Dictionary

SODIUM PCA

How much products actually contain

6 products state the amountmedian 0.041%

under 0.01% 3
0.01–0.1% 2
0.1–1% 0
1% or more 1

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 315 list it before the 1% line and 266 after it (usually 1% or less).

Products using this ingredient

12 of 576 confirmed · likeliest to carry enough first · See all 576

Definition

US FDA substance register · UNII 1V74VH163T · registered name SODIUM PIDOLATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Softens hairHAIR CONDITIONINGReduces staticANTISTATICKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGDraws in and holds moistureHUMECTANT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of PCA (2-pyrrolidone-5-carboxylic acid) and its Salts as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Safety Assessment for PCA and Sodium PCA

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ＰＣＡ－Ｎａ: 本品は、ピロリドンカルボン酸（ＰＣＡ（＊））のナトリウム塩であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

SODIUM PCAINCI소듐피씨에이Korean label name (MFDS standard)L-Proline, 5-oxo-, monosodium saltSynonymＰＣＡ－ＮａJapanese labelling name

CAS No.chemical registry number: 28874-51-3
CAS No.chemical registry number: 54571-67-4
EC No.EU chemical inventory number: 249-277-1
DTXSIDUS EPA chemical ID: DTXSID50183074
DTXCIDUS EPA compound ID: DTXCID60105565

IUPAC: Sodium 5-oxo-L-prolinate
Molecular formula: C5H6NNaO3
Molecular weight: 151.097 g/mol

What products actually use it for

What the 54 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner42
Humectant7
Anti-static agent5

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to