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成分词典

成分词典

SODIUM SALICYLATE

Sodium salicylate is an organic molecular entity.

分子结构

产品中实际含有多少

暂无产品标示该成分含量。

含该成分的产品中,6 款将其列在 1% 线之前,67 款列在之后(通常不超过 1%)。

含有此成分的产品

已确认 71 款中的 12 款 · 按含量充足程度排序 · 查看全部 71 款

定义

美国FDA 物质登记 · UNII WIQ1H85SYP · 登记名称 Sodium Salicylate · 单一化学物质

来源: 美国FDA 物质识别码(UNII)

Sodium Salicylate is the sodium salt of salicylic acid that conforms to the formula:

Sodium salicylate is an organic molecular entity.

来源: PubChem

化妆品中的作用

使酒精不可饮用DENATURANT防止产品中微生物滋生PRESERVATIVE

安全与法规参考

限用
韩国 · 中国

来源: 韩国食药处 化妆品法规信息

阿根廷 · 巴西

  • Maximum concentration permitted at final product : 0.5% (expressed as acid)
  • Other limitations and requirements : Prohibited in products for children under 3 years of age, except for shampoos.
  • Use conditions and warnings that must appear on the label : Products for use Adults: "Do not use in children" For products aimed at children: "Do not use in children under three years of age (except shampoo)"

东盟

  • Field of application and/or use : (a) Rinse-off hair products (b) Other products except body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant (c) Body lotion, eye shadow, mascara, eyeliner, lipstick, roll-on deodorant
  • Maximum authorised concentration in the finished cosmetic product : (a) 3.0 % (b) 2.0% (c) 0.5%
  • Other limitations and requirements : (a) (b) (c) Not to be used in preparations for children under 3 years of age. Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Not to be used in oral products. For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product. These levels are inclusive of any use of salicylic acid. As a preservative, see Annex VI, Part 1, No 3
  • Conditions of use and warning which must be printed on the labels : (a) (b) (c) Not to be used for children under three years of age
  • Solely for products which might be used for children
  • Maximum authorised concentration in the finished cosmetic product : Salicylic acid: 0,5 % (acid) Salicylic acid salts: 0,5 % (acid)
  • Other limitations and requirements : Salicylic acid: Not to be used in products for children under 3 years of age. Not to be used in oral products. Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Salicylic acid salts: Not to be used in products for children under 3 years of age, except for shampoos.
  • Conditions of use and warning which must be printed on the labels : Salicylic acid: Not to be used for children under 3 years of age Salicylic acid salts: Not to be used for children under 3 years of age

台湾

  • 倘前述三國家地區政府管理有差異時,則採其中限量規定方式最安全者。
  • ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
  • 用途 : 防腐

日本

  • 每100g最大配合量(Maximum amount of ingredient per 100 g) : 1.0 as total(合計量として1.0)

欧盟

  • Maximum concentration in ready for use preparation : Salicylic acid: 0,5 % (acid) Salicylic acid salts: 0,5 % (acid)
  • Other : Not to be used in products for children under 3 years of age, except for shampoos
  • Wording of conditions of use and warnings : Salicylic acid: Not to be used for children under 3 years of age **Solely for products which might be used for children under 3 years of age. Salicylic acid salts: Not to be used for children under 3 years of age ***Solely for products which might be used for children under 3 years of age and which remain in prolonged contact with the skin.

来源: 韩国食药处 化妆品法规信息

未列入韩国有毒物质 GHS 分类 · 现有化学物质

来源: 韩国有毒物质 GHS 信息(环境公团)

Restriction V/3 · SCCS opinion: Opinion concerning Salicylic Acid; OPINION ON salicylic acid (CAS 69-72-7) Submission I

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Amended Safety Assessment of Salicylic Acid and Salicylates as Used in Cosmetics

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Report on the Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate

来源: 美国CIR 安全性评估

详细资料——标示名称、识别编号、物性、试验记录、文献

官方标示名称和定义

日本化妆品工业联合会标示名称 サリチル酸Na: 本品は、サリチル酸(*)のナトリウム塩であり、次の化学式で表される。

来源: 日本化妆品工业联合会标示名称

别名和识别信息

SODIUM SALICYLATEINCI소듐살리실레이트韩国标示名称(食药处标准名)Benzoic acid, 2-hydroxy-, sodium salt (1:1)同义名サリチル酸Na日本标示名称
CAS No.化学物质登记号
54-21-7
EC No.欧盟化学品目录编号
200-198-0
DTXSID美国EPA化学品编号
DTXSID5021708
DTXCID美国EPA化合物编号
DTXCID701708
IUPAC
Sodium 2-hydroxybenzoate
分子式
C7H5NaO3
分子量
160.104 g/mol

实测物性

性状
Dry Powder · 固体
颜色
白色
pH
6.21 (@ 27 ℃, 1 %)
蒸气压
0.0000000000368 ㎜Hg (@ 25 ℃, 估算值)
溶解度
125000 ㎎/ℓ (@ 25 ℃)
蒸气密度
5.53
比重
0.56 (@ 25 ℃)
正辛醇/水分配系数(Kow)
-1.43
分解温度
213 ℃
分子量
160.10

这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。

来源: PubChem · 韩国安全保健公团 安全数据表

产品实际使用的用途

这是向美国 EPA 申报含该成分的 5 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。

  • Preservative5

来源: 美国EPA CompTox

刺激与致敏试验记录

记录有皮肤试验 5 项、眼部试验 9 项。

归类为低6 项

试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。

查看全部 14 项试验
  • Not likely to be sensitizing
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Patch test
  • Not likely to be sensitizing
    skin sensitisation · Screening · according to other guideline: as mentioned below
  • Category 6.3B (Category 3)
    Skin Irritation · Read Across
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) according to
  • Severe Irritation
    eye irritation: in vivo · Screening · other guideline: as mentioned below according to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · other guideline: Draize method according to
  • Severe Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vivo · Screening · other guideline: Draize test according to
  • Severe Irritation
    eye irritation: in vitro / ex vivo · Screening · other guideline: The Vitrigel-EIT method according to
  • Category 6.4A (Category 2A)
    Eye Irritation · Read Across
  • Serious eye damage/eye irritation - Category 2B
    Eye Irritation · Screening
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vitro / ex vivo · Screening · other guideline: Short time exposure (STE) test according to

来源: 美国EPA CompTox

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