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Ingredients

Ingredient Dictionary

SODIUM THIOGLYCOLATE

Sodium thioglycolate is an organic sodium salt having thioglycolate(1) as the counterion.

Molecular structure

Definition

Sodium thioglycolate is an organic sodium salt having thioglycolate(1) as the counterion. It has a role as a reducing agent. It contains a thioglycolate(1-).

Source: PubChem

US FDA substance register · UNII D94M78P69V · registered name SODIUM THIOGLYCOLATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Curls or straightens hairHAIR WAVING OR STRAIGHTENINGSlows spoilage by oxygenANTIOXIDANTDissolves hair to remove itDEPILATORYReduces other ingredientsREDUCING

Safety & regulatory references

Restricted
South Korea

Source: MFDS (Korea) cosmetic regulatory information

Argentina · Brazil

  • Field of application and/or use : (a) Products for hair straightening or waving: 1. General use 2. Professional use (b) Depilatories (c) Other products for hair care which are removed after application
  • Maximum concentration permitted at final product : (a) 1. 8% ready to use pH 7 to 9.5 2. 11% ready to use pH 7 to 9.5 (b) 5% ready to use pH 7 to 12.7 (c) 2% .ready to use pH 7 to 9.5 The indicated percentages are calculated as thioglycolic acid
  • Other limitations and requirements : a, b and c) In the USAGE must obligatorily the following information recorded: - Avoid contact with eyes. - In case of contact with eyes, rinse immediately with plenty water and consult a doctor - and c) Wear suitable gloves
  • Use conditions and warnings that must appear on the label : a), b) and c) - Contains thioglycolic acid salts - Follow instructions - Keep out of reach of children - Only for professional use (where appropriate)

ASEAN

  • Field of application and/or use : (a) Hair waving or straightening products: 1. General use 2. Professional use (b) Depilatories (c) Other hair care products which are removed after application
  • Maximum authorised concentration in the finished cosmetic product : (a) 1. 8% ready for use at pH 7 – 9.5 2. 11% ready for use at pH 7- 9.5 (b) 5% ready for use at pH 7-12.7 (c) 2% ready for use at pH 7-9.5 For general use of hair waving or straightening products the maximum concentration for combination of Thioglycolic acid and thiolactic acid must not exceed 8% calculated as Thioglycolic Acid.
  • Other limitations and requirements : (a) (b) (c) The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • Avoid contact with eyes • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves (a) and (c) only.
  • Conditions of use and warning which must be printed on the labels : (a) • Contains thioglycolate • Follow the instructions • Keep out of reach of children. • For professional use only. (b) and (c) • Contains thioglycolate • Follow the instructions • Keep out of reach of children

Canada

  • Conditions of Use by product type : (a) Eyelash curling products (b) Hair dyes, waving or straightening products (c) Hair dyes, waving or straightening products for professional use (d) Depilatory products
  • Maximum Concentration Permitted : ((a) 11% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (b) 8% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (c) 11% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (d) 5% (as thioglycolic aci(d) with a pH less than or equal to 12.7
  • Warnings and Cautionary Statements: (to the effect of) : (a) "For professional use only.", "Avoid direct skin contact, wear suitable gloves.", "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention." (b)"Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye." (c) "For professional use only." "Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye." d) "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention."

China

  • Maximum concentration : (a)

European Union

  • Product Type, body parts : (a) Hair products (b) Depilatories (c) Hair rinse-off products (d) Products intended for eyelash waving
  • Maximum concentration in ready for use preparation : (a) 1) 8% 2) 11% (b) 5% (c) 2% (d) 11% The abovementioned percentages are calculated as thioglycollic acid
  • Other : (a) General use ready for use pH 7 to 9.5 Professional use ready for use pH 7 to 9.5 (b) ready for use pH 7 to 12.7 (c) ready for use pH 7 to 9.5 (d) ready for use pH 7 to 9,5
  • Wording of conditions of use and warnings : Condition of use: (a) (b) (c) Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice (a) (c) (d) Wear suitable gloves Warnings to be printed on the label: (a) (b) (c) Contains thioglycolate Follow the instructions Keep out of reach of children (a) (d) For professional use only: Cotains thiglycolata, folow the instruction.

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction III/2a · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name チオグリコール酸Na: 本品は、次の化学式で表される有機塩である。

Source: JCIA labelling names (Japan)

Names & identifiers

SODIUM THIOGLYCOLATEINCI소듐티오글라이콜레이트Korean label name (MFDS standard)Acetic acid, mercapto-, monosodium saltSynonymチオグリコール酸NaJapanese labelling name
CAS No.chemical registry number
367-51-1
EC No.EU chemical inventory number
206-696-4
DTXSIDUS EPA chemical ID
DTXSID3026142
DTXCIDUS EPA compound ID
DTXCID806142
IUPAC
Sodium sulfanylacetate
Molecular formula
C2H3NaO2S
Molecular weight
114.09 g/mol

Measured properties

Appearance
Thioglycolic acid, sodium salt is a white powder with a slight odor. Used in cold-waving of hair and as a dipilatory. · Liquid
Melting point
greater than 572 °F (NTP, 1992)
Solubility
Very soluble (NTP, 1992)
Melting/freezing point
220 ℃
Molecular weight
114.10

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 13 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Degradant/impurity (EPA)4
  • Tanning agents not otherwise specified2
  • Reducing agent1
  • Hair waving or straightening (EPA)1
  • Depilatory (EPA)1
  • Cleaning agent1
  • Chelating agent1
  • Antioxidant1
1 other uses
  • Processing aids not otherwise specified1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 2 eye studies are on record.

Classed as highly irritating2Classed as moderate1

The study conclusions largely agree (67%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Skin irritation - category 2
    Skin Irritation · Screening
  • Skin sensitisation - category 1
    Skin Sensitization · Screening
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • Moderate or Mild Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • Eye irritation - category 2A
    Eye Irritation · Screening
  • Moderate or Mild Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to

Source: US EPA CompTox dashboard

Related literature

Linked databases 19