Sodium thioglycolate is an organic sodium salt having thioglycolate(1) as the counterion.
定义
Sodium thioglycolate is an organic sodium salt having thioglycolate(1) as the counterion. It has a role as a reducing agent. It contains a thioglycolate(1-).
来源: PubChem
美国FDA 物质登记 · UNII D94M78P69V · 登记名称 SODIUM THIOGLYCOLATE · 单一化学物质
化妆品中的作用
安全与法规参考
- 限用
- 韩国
来源: 韩国食药处 化妆品法规信息
阿根廷 · 巴西
- Field of application and/or use : (a) Products for hair straightening or waving: 1. General use 2. Professional use (b) Depilatories (c) Other products for hair care which are removed after application
- Maximum concentration permitted at final product : (a) 1. 8% ready to use pH 7 to 9.5 2. 11% ready to use pH 7 to 9.5 (b) 5% ready to use pH 7 to 12.7 (c) 2% .ready to use pH 7 to 9.5 The indicated percentages are calculated as thioglycolic acid
- Other limitations and requirements : a, b and c) In the USAGE must obligatorily the following information recorded: - Avoid contact with eyes. - In case of contact with eyes, rinse immediately with plenty water and consult a doctor - and c) Wear suitable gloves
- Use conditions and warnings that must appear on the label : a), b) and c) - Contains thioglycolic acid salts - Follow instructions - Keep out of reach of children - Only for professional use (where appropriate)
东盟
- Field of application and/or use : (a) Hair waving or straightening products: 1. General use 2. Professional use (b) Depilatories (c) Other hair care products which are removed after application
- Maximum authorised concentration in the finished cosmetic product : (a) 1. 8% ready for use at pH 7 – 9.5 2. 11% ready for use at pH 7- 9.5 (b) 5% ready for use at pH 7-12.7 (c) 2% ready for use at pH 7-9.5 For general use of hair waving or straightening products the maximum concentration for combination of Thioglycolic acid and thiolactic acid must not exceed 8% calculated as Thioglycolic Acid.
- Other limitations and requirements : (a) (b) (c) The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • Avoid contact with eyes • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves (a) and (c) only.
- Conditions of use and warning which must be printed on the labels : (a) • Contains thioglycolate • Follow the instructions • Keep out of reach of children. • For professional use only. (b) and (c) • Contains thioglycolate • Follow the instructions • Keep out of reach of children
加拿大
- Conditions of Use by product type : (a) Eyelash curling products (b) Hair dyes, waving or straightening products (c) Hair dyes, waving or straightening products for professional use (d) Depilatory products
- Maximum Concentration Permitted : ((a) 11% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (b) 8% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (c) 11% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (d) 5% (as thioglycolic aci(d) with a pH less than or equal to 12.7
- Warnings and Cautionary Statements: (to the effect of) : (a) "For professional use only.", "Avoid direct skin contact, wear suitable gloves.", "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention." (b)"Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye." (c) "For professional use only." "Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye." d) "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention."
中国
- 最大配合量 : (a)
欧盟
- Product Type, body parts : (a) Hair products (b) Depilatories (c) Hair rinse-off products (d) Products intended for eyelash waving
- Maximum concentration in ready for use preparation : (a) 1) 8% 2) 11% (b) 5% (c) 2% (d) 11% The abovementioned percentages are calculated as thioglycollic acid
- Other : (a) General use ready for use pH 7 to 9.5 Professional use ready for use pH 7 to 9.5 (b) ready for use pH 7 to 12.7 (c) ready for use pH 7 to 9.5 (d) ready for use pH 7 to 9,5
- Wording of conditions of use and warnings : Condition of use: (a) (b) (c) Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice (a) (c) (d) Wear suitable gloves Warnings to be printed on the label: (a) (b) (c) Contains thioglycolate Follow the instructions Keep out of reach of children (a) (d) For professional use only: Cotains thiglycolata, folow the instruction.
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Restriction III/2a · Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 チオグリコール酸Na: 本品は、次の化学式で表される有機塩である。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 367-51-1
- EC No.欧盟化学品目录编号
- 206-696-4
- DTXSID美国EPA化学品编号
- DTXSID3026142
- DTXCID美国EPA化合物编号
- DTXCID806142
- IUPAC
- Sodium sulfanylacetate
- 分子式
- C2H3NaO2S
- 分子量
- 114.09 g/mol
实测物性
- 性状
- Thioglycolic acid, sodium salt is a white powder with a slight odor. Used in cold-waving of hair and as a dipilatory. · Liquid
- 熔点
- greater than 572 °F (NTP, 1992)
- 溶解性
- Very soluble (NTP, 1992)
- 熔点/凝固点
- 220 ℃
- 分子量
- 114.10
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 13 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Degradant/impurity (EPA)4
- Tanning agents not otherwise specified2
- Reducing agent1
- Hair waving or straightening (EPA)1
- Depilatory (EPA)1
- Cleaning agent1
- Chelating agent1
- Antioxidant1
其余用途 1 项
- Processing aids not otherwise specified1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 6 项、眼部试验 2 项。
试验结论基本一致(67%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 8 项试验
- SkinSens1
Skin Sensitization · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Skin irritation - category 2
Skin Irritation · Screening - Skin sensitisation - category 1
Skin Sensitization · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Eye irritation - category 2A
Eye Irritation · Screening - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
来源: 美国EPA CompTox
相关文献
- Comparative Assessments of New Hair-Straightening Cosmetic Formulations on Wavy Type 2 Hair · 2024
- Understanding the dynamics of keratin weakening and hydrolysis by proteases · 2018
- Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thio · 2009
- Developmental toxicity evaluation of sodium thioglycolate administered topically to Sprague-Dawley (CD) rats and New Zealand White rabbits. · 2003
- Percutaneous toxicity of thioglycolate mixtures in rabbits. · 1979