Phloxine O is a xanthene dye that is fluorescein in which the hydrogens at positions 2',4',5' and 7' are replaced by bromo groups, and the hydrogens at positions 4,5,6 and 7 are replaced by chloro groups.
Definition
US FDA substance register · UNII 2LRS185U6K · registered name D&C RED NO. 27 · single chemical substance
Phloxine O is a xanthene dye that is fluorescein in which the hydrogens at positions 2',4',5' and 7' are replaced by bromo groups, and the hydrogens at positions 4,5,6 and 7 are replaced by chloro groups. It is a red synthetic pigment which is widely used in colored cosmetics (e.g. lipsticks and blushers). It has a role as a fluorescent dye. It is a polyphenol, a tetrachlorobenzene, a dibromobenzene, a gamma-lactone, a xanthene dye, an oxaspiro compound, an organic heteropentacyclic compound and a member of 2-benzofurans. It is functionally related to a fluorescein (lactone form).
Source: PubChem
Solvent Red 48 is classed chemically as a fluoran color. It conforms to the formula. (To identify the colorant allowed for use in the European Union (EU), the INCI Name CI 45410 must be used, except for hair dye products).
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 13473-26-2
- EC No.EU chemical inventory number
- 236-747-6
- DTXSIDUS EPA chemical ID
- DTXSID2031089
- DTXCIDUS EPA compound ID
- DTXCID0011089
- IUPAC
- 2',4',5',7'-Tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[[2]benzofuran-1,9'-xanthen]-3-one
- Molecular formula
- C20H4Br4Cl4O5
- Molecular weight
- 785.66 g/mol
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: OECD Guideline 402 (Acute Dermal Toxicity) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: as mentioned below according to - Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: As mentioned below - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as below
Source: US EPA CompTox dashboard