Spermidine is a triamine that is the 1,5,10-triaza derivative of decane.
Definition
US FDA substance register · UNII U87FK77H25 · registered name SPERMIDINE · single chemical substance
Spermidine is a triamine that is the 1,5,10-triaza derivative of decane. It has a role as an autophagy inducer, a geroprotector and a fundamental metabolite. It is a triamine and a polyazaalkane. It is a conjugate base of a spermidine(3+).
Source: PubChem
Spermidine is the organic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 124-20-9
- EC No.EU chemical inventory number
- 204-689-0
- DTXSIDUS EPA chemical ID
- DTXSID4036645
- DTXCIDUS EPA compound ID
- DTXCID2016645
- IUPAC
- N~1~-(3-Aminopropyl)butane-1,4-diamine
- Molecular formula
- C7H19N3
- Molecular weight
- 145.25 g/mol
Measured properties
- Appearance
- Solid · liquid
- Boiling point
- 129 °C at 1.40E+01 mm Hg
- Melting point
- < 25 °C
- Initial boiling point and range
- 128~130 ℃ ( at 14 mmHg)
- Flash point
- 110 ℃
- Vapour pressure
- 0.03 ㎜Hg (25 C)
- Relative density
- 0.925
- n-Octanol/water partition coefficient (Kow)
- -0.84
- Molecular weight
- 145.25
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
- Softener and conditioner1
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - SkinIrr2
Skin Irritation · QSAR Predicted - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Spermidine promotes melanin production through an MITF signalling pathway · 2021
- Quantitative Spermidine Detection in Cosmetics using an Organic Transistor‐Based Chemical Sensor · 2024
- Spermidine promotes lysozyme tolerance and acid stress resistance in Streptococcus pyogenes M3. · 2022
- Potent trophic activity of spermidine supramolecular complexes in in vitro models. · 2013
- The effects of intradermal injections of spermidine on the growth rate of fibres and mitosis of wool follicles in Merino lambs · 2002
Linked databases 17
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese