Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration.
Definition
Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a mouse metabolite and a human metabolite. It is a conjugate base of a sphinganine(1+).
Source: PubChem
US FDA substance register · UNII YT0ZSD64HM · registered name SPHINGANINE · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name スフィンガニン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 3102-56-5
- CAS No.chemical registry number
- 764-22-7
- EC No.EU chemical inventory number
- 212-116-0
- DTXSIDUS EPA chemical ID
- DTXSID501016568
- DTXCIDUS EPA compound ID
- DTXCID301474756
- IUPAC
- (2S,3R)-2-Aminooctadecane-1,3-diol
- Molecular formula
- C18H39NO2
- Molecular weight
- 301.515 g/mol
Measured properties
- Appearance
- Solid
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- The Interplay between Bioactive Sphingolipids in the Psoriatic Skin and the Severity of the Disease · 2023
- Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu · 2020
- Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis · 2013
- Effects of sphingoid bases on the sphingolipidome in early keratinocyte differentiation · 2013
- Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis · 2013
Linked databases 16
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English