Ingredient Dictionary

SPIRONOLACTONE

Spironolactone can cause cancer according to state or federal government labeling requirements.

Definition

Spironolactone can cause cancer according to state or federal government labeling requirements.

Source: PubChem

US FDA substance register · UNII 27O7W4T232 · registered name Spironolactone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 4

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/4

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

SPIRONOLACTONEINCI스피로노락톤Korean label name (MFDS standard)

CAS No.chemical registry number: 52-01-7
EC No.EU chemical inventory number: 200-133-6
DTXSIDUS EPA chemical ID: DTXSID6034186
DTXCIDUS EPA compound ID: DTXCID4014186

IUPAC: S-[(1R,3aS,3bR,4R,9aR,9bS,11aS)-9a,11a-Dimethyl-5',7-dioxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydrospiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-4-yl] ethanethioate
Molecular formula: C24H32O4S
Molecular weight: 416.58 g/mol

Measured properties

Appearance: Solid · Crystals from methanol
Odour: Mild mercaptan-like odor
Boiling point: 134 °C
Melting point: 198-207 · 134-135 °C
Solubility: Soluble in most organic solvents · Soluble in ethyl acetate and ethanol, slightly soluble in methanol
Stability: STABLE IN AIR
Melting/freezing point: 134~135 ℃
n-Octanol/water partition coefficient (Kow): 2.78
Molecular weight: 416.59

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)3
No specific technical function1

Source: US EPA CompTox dashboard