How much products actually contain
No product states its amount yet.
Of the products containing it, 3 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
3 of 3 confirmed · likeliest to carry enough first
Definition
US FDA substance register · UNII 0ZP13EBC5Y · registered name SUBTILISIN · protein
Enzymes, subtilisin
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name スブチリシン: 本品は、枯草菌 Bacillus subtilis 又は Bacillus licheniformis から得られる酵素である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 9014-01-1
- EC No.EU chemical inventory number
- 232-752-2
- DTXSIDUS EPA chemical ID
- DTXSID6052790
Measured properties
- Appearance
- solid
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 197 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Chemical reaction regulator140
- Cleaning agent52
- Softener and conditioner3
- Pharmaceutical (EPA)2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 5 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 12 studies
- Skin Irrit. 2
Skin Irritation · Authoritative - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.3B (Category 3)
Skin Irritation · Read Across - Skin corrosion/irritation - Category 2
Skin Irritation · Screening - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: according to - Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1987 according to - Serious eye damage/eye irritation - Category 2B
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Category 2B
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Structural, Functional, and Mutational Studies of a Potent Subtilisin Inhibitor from Budgett's Frog, Lepidobatrachus laevis. · 2023
- Comprehensive biochemical, molecular and structural characterization of subtilisin with fibrinolytic potential in bioprocessing · 2025
- Cellular composition of an experimental chemical injury to the cornea after exposure to PEGylated hyaluronidase and subtilisin enzymes · 2023
- Injection of an improperly stored proprotein convertase subtilisin/kexin type 9 monoclonal antibody in a patient with secondary dyslipidemia from nephrotic syndrome: a case report · 2023
- Efficacy and safety profile of a subtilisin protease produced by fermentation in Bacillus licheniformis to be used as a feed additive · 2022
Linked databases 16
- AICIS inventory notices (Australia)
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata