Sucralose is a disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.
How much products actually contain
No product states its amount yet.
Of the products containing it, 3 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
4 of 4 confirmed · likeliest to carry enough first
Definition
US FDA substance register · UNII 96K6UQ3ZD4 · registered name Sucralose · single chemical substance
Sucralose is a disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond. It has a role as a xenobiotic, a sweetening agent and an environmental contaminant. It is an organochlorine compound and a disaccharide derivative.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of Monosaccharides, Disaccharides and Related Ingredients as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name スクラロース: 本品は、次の化学式で表される糖の塩化物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 56038-13-2
- EC No.EU chemical inventory number
- 259-952-2
- DTXSIDUS EPA chemical ID
- DTXSID1040245
- DTXCIDUS EPA compound ID
- DTXCID9020245
- IUPAC
- 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside
- Molecular formula
- C12H19Cl3O8
- Molecular weight
- 397.63 g/mol
Measured properties
- Appearance
- White to off-white, practically odourless, crystalline powder. · Syrup, Anhydrous form is solid, [Merck Index] White to off-white solid, [HSDB] White powder, [Sigma-Aldrich MSDS]
- Melting point
- 130 °C · MP: 36.5 °C /Sucralose pentahydrate/
- Solubility
- Freely soluble in water, methanol and ethanol, Slightly soluble in ethyl acetate · Freely soluble in methanol, alcohol, slightly soluble in ethyl acetate
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 76 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient73
- Softener and conditioner2
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinIrr2
Skin Irritation · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Cellular mechanisms underlying the effects of sucralose on keratinocyte proliferation and its contributing roles in epidermal regeneration · 2025
- Chronic sugar exposure increases daily intake of sugars but decreases avidity for sweeteners in mice. · 2023
- Sweet surfactants I: Fatty acid esters of sucralose. · 2021
- COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS · 2021
- Non-nutritive sweetener sucralose chronic consumption is able to reduce the deleterious effect of high-fat diet on body composition, glucose metabolism and vascular function in C57BL/6JR mice · 2020
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
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