Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen.
Definition
Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. It has a role as an alpha-adrenergic agonist and a plant metabolite. It is a member of ethanolamines, a member of phenols and a phenethylamine alkaloid. It is a conjugate base of a synephrinium.
Source: PubChem
US FDA substance register · UNII PEG5DP7434 · registered name Oxedrine · single chemical substance
Synephrine is the organic compound
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea
Source: MFDS (Korea) cosmetic regulatory information
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 94-07-5
- DTXSIDUS EPA chemical ID
- DTXSID0030588
- DTXCIDUS EPA compound ID
- DTXCID8010588
- IUPAC
- 4-[1-Hydroxy-2-(methylamino)ethyl]phenol
- Molecular formula
- C9H13NO2
- Molecular weight
- 167.208 g/mol
Measured properties
- Appearance
- Solid
- Dissociation constant
- 9.6
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Humectant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Application of Synephrine to Grape Increases Anthocyanin via Production of Hydrogen Peroxide, Not Phytohormones · 2024
- Synephrine potentiates lidocaine‐induced cutaneous analgesia via α‐adrenergic receptors in male rats · 2026
- Pharmacological and Pharmacognostic of Citrus aurantium A Comprehensive Review of Its Medicinal Properties and Safety Profile · 2024
- Unshiu unripe fruit extract or synephrine or inflammatory skin diseases or prophylactic composition containing the salt as an active ingredient · 2014
- Proliferative Responses of Mesangial Cells to Growth Factors during Compensatory versus Dietary Hypertrophy · 2000
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese