Syringic acid is a dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.
Definition
Syringic acid is a dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid. It has a role as a plant metabolite. It is a member of benzoic acids, a member of phenols and a dimethoxybenzene. It is functionally related to a gallic acid. It is a conjugate acid of a syringate.
Source: PubChem
US FDA substance register · UNII E390O181H5 · registered name SYRINGIC ACID · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 530-57-4
- EC No.EU chemical inventory number
- 208-486-8
- DTXSIDUS EPA chemical ID
- DTXSID0060191
- DTXCIDUS EPA compound ID
- DTXCID2041337
- IUPAC
- 4-Hydroxy-3,5-dimethoxybenzoic acid
- Molecular formula
- C9H10O5
- Molecular weight
- 198.174 g/mol
Measured properties
- Appearance
- Light brown powder, [Sigma-Aldrich MSDS] · Solid
- Boiling point
- 440.00 °C. @ 760.00 mm Hg
- Melting point
- 206 - 209 °C
- Colour
- White to beige powder
- Melting/freezing point
- 206~209 ℃ (25deg C)
- Vapour pressure
- 0.00000291 ㎜Hg (25deg C)
- Water solubility
- 5780 ㎎/ℓ (25deg C)
- n-Octanol/water partition coefficient (Kow)
- 1.04
- Molecular weight
- 198.19
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient1
- Antioxidant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Phyto Phospholipid Complex Formulation and Molecular Docking-Based Validation of Syringic Acid from Oxalis corniculata: a Bioactive Strategy against in Vitro Oxidative Stress · 2026
- Syringic acid protective role: Combatting oxidative stress induced by UVB radiation in L-929 fibroblasts. · 2025
- Oral phytochemicals as photoprotectants in UVR exposed hairless mice: A study of hesperidin methyl chalcone, phloroglucinol, and syringic acid. · 2023
- Unraveling the pharmaceutical and clinical relevance of the influence of syringic acid loaded linoleic acid transferosomes on acne. · 2023
- Syringic Acid Alleviates Cesium-Induced Growth Defect in Arabidopsis · 2020
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese