What is this ingredient?

미국 FDA 물질 등록 · UNII 76N22HKP3X · 등록명 TERT-BUTYL ACETATE · 단일 화학물질

All ingredients

Ingredient Dictionary

T-BUTYL ACETATE

Definition

US FDA substance register · UNII 76N22HKP3X · registered name TERT-BUTYL ACETATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report of the Cosmetic Ingredient Reveiw Expert Panel on the Safety Assessment of Methyl Acetate

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

T-BUTYL ACETATEINCIAcetic acid, 1,1-dimethylethyl esterSynonym

CAS No.chemical registry number: 540-88-5
EC No.EU chemical inventory number: 208-760-7
DTXSIDUS EPA chemical ID: DTXSID1022055
DTXCIDUS EPA compound ID: DTXCID702055

IUPAC: tert-Butyl acetate
Molecular formula: C6H12O2
Molecular weight: 116.16 g/mol

Measured properties

Appearance: Tert-butyl acetate is a colorless liquid with a mild odor. Floats on water. Produces irritating vapor. (USCG, 1999) · Liquid, CBI
Odour: Fruity odor
Boiling point: 208 °F at 760 mmHg (USCG, 1999) · 95.1 °C
Solubility: Insoluble (NIOSH, 2024) · Soluble in ethanol, ethyl ether, chloroform, acetic acid
Density: 0.8665 at 68 °F 0.8593 at 25 °C (USCG, 1999) - Less dense than water, will float · 0.8665 g/cu cm at 20 °C
Stability: Heat /contributes to instability/.
Colour: colourless
Melting/freezing point: &amp, lt, 25 ℃
Initial boiling point and range: 97.8 ℃
Flash point: 15.5 ℃(c.c.)
Upper/lower flammability or explosive limits: 1.5 / 7.3 %
Vapour pressure: 47 ㎜Hg (25℃)
Vapour density: 4.0
Relative density: 0.86
n-Octanol/water partition coefficient (Kow): 1.76
Auto-ignition temperature: 425 ℃
Viscosity: &amp, lt, 1 (25℃)
Molecular weight: 116.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 13 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent8
Processing aids not otherwise specified2
Solubility enhancer2
Fuel1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 3 eye studies are on record.

Classed as low3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OTS 798.4470 (Acute Dermal Irritation) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation)
Not classified
Skin Irritation · Screening
Category 6.3B (Category 3)
Skin Irritation · Read Across
Classification not possible
Skin Sensitization · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OTS 798.4500 (Acute Eye Irritation) according to
Category 2B
Eye Irritation · Screening